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HomoloGene:445. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MPZ,  H.sapiens
myelin protein zero
NP_000521.2
248 aa
MPZ,  P.troglodytes
myelin protein zero
XP_001173975.1
258 aa
LOC719969,  M.mulatta
myelin protein P0-like
XP_001118030.1
256 aa
MPZ,  C.lupus
myelin protein zero
XP_545771.1
258 aa
MPZ,  B.taurus
myelin protein zero
NP_001072975.1
248 aa
Mpz,  M.musculus
myelin protein zero
NP_032649.2
248 aa
Mpz,  R.norvegicus
myelin protein zero
NP_058723.1
248 aa
LOC100859605,  G.gallus
myelin protein P0-like
XP_003643863.1
131 aa
mpz,  X.tropicalis
myelin protein zero
NP_001072741.1
243 aa
mpz,  D.rerio
myelin protein zero
NP_919342.1
203 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Charcot-Marie-Tooth disease, type 1B.
Dejerine-Sottas syndrome.
Roussy-Levy syndrome.
Neuropathy, congenital hypomyelinating.
Charcot-Marie-Tooth disease, type 2I.
Charcot-Marie-Tooth disease, type 2J.
Charcot-Marie-Tooth disease, dominant intermediate 3.



Publications
Articles associated with genes and sequences of this homology group.

Phenotypic presentation of the Ser63Del MPZ mutation.
Miller LJ, et al. J Peripher Nerv Syst 17, 197-200 (2012).
[Clinical-genetic correlations in the hereditary motor-sensor neuropathy caused by mutations in the MPZ (P0) gene].
Milovidova TB, et al. Zh Nevrol Psikhiatr Im S S Korsakova 111, 48-55 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Myelin-PO_C (pfam10570)
  Myelin-PO cytoplasmic C-term p65 binding region.
Ig (cl11960)
  Immunoglobulin domain.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mpz includes H.sapiens MPZ and R.norvegicus Mpz.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 10 species)
Actinopterygii - bony fishes (8 transcripts, 7 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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