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HomoloGene:9689. Gene conserved in Eukaryota Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

DUOX2,  H.sapiens
dual oxidase 2
1548 aa
DUOX2,  P.troglodytes
dual oxidase 2
1548 aa
LOC713906,  M.mulatta
dual oxidase 2-like
1385 aa
DUOX2,  C.lupus
dual oxidase 2
1549 aa
DUOX2,  B.taurus
dual oxidase 2
1578 aa
Duox2,  M.musculus
dual oxidase 2
1517 aa
Duox2,  R.norvegicus
dual oxidase 2
1517 aa
duox2,  X.tropicalis
dual oxidase 2
1517 aa
Duox,  D.melanogaster
Dual oxidase
1537 aa
DUOX,  A.gambiae
1475 aa
bli-3,  C.elegans
1497 aa
duox-2,  C.elegans
1503 aa
RBOHB,  A.thaliana
843 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Hypothyroidism, congenital, due to DUOX2 deficiency.

Articles associated with genes and sequences of this homology group.

Congenital hypothyroidism caused by a novel mutation of the dual oxidase 2 (DUOX2) gene.
Yoshizawa-Ogasawara A, et al. J Pediatr Endocrinol Metab 26, 45-52 (2013).
[DUOX2 gene mutation in patients with congenital goiter with hypothyroidism].
Lü ZP, et al. Zhonghua Er Ke Za Zhi 49, 943-6 (2011).
Structural stability and heme binding potential of the truncated human dual oxidase 2 (DUOX2) peroxidase domain.
Meitzler JL & Ortiz de Montellano PR. Arch Biochem Biophys 512, 197-203 (2011).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NADPH_Ox (pfam08414)
  Respiratory burst NADPH oxidase.
Ferric_reduct (pfam01794)
  Ferric reductase like transmembrane component.
FRQ1 (COG5126)
  Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only].
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
FNR_like (cl06868)
  Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
NAD_binding_6 (pfam08030)
  Ferric reductase NAD binding domain.
Ferric_reduct (cl01043)
  This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.
FNR_like (cl06868)
  Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
S-100 (cl08302)
  S-100: S-100 domain, which represents the largest family within the superfamily of proteins carrying the Ca-binding EF-hand motif. Note that this S-100 hierarchy contains only S-100 EF-hand domains, other EF-hands have been modeled separately. S100 ...
An_peroxidase_like (cl14561)
  Animal heme peroxidases and related proteins.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Duox2 includes H.sapiens DUOX2 and R.norvegicus Duox2.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (8 transcripts, 6 species)
Ascidiacea - tunicates (4 transcripts, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Insecta - insects (7 transcripts, 6 species)
Maxillopoda - crustaceans (2 transcripts, 1 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Gastropoda - gastropods (6 transcripts, 2 species)

Polychaeta - segmented worms (6 transcripts, 1 species)

Chromadorea - nematodes (3 transcripts, 2 species)

Echinoidea - sea urchins (3 transcripts, 2 species)

Liliopsida - monocots (15 transcripts, 8 species)
Eudicotyledons - eudicots (5 transcripts, 4 species)
Coniferopsida - conifers (2 transcripts, 1 species)




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