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HomoloGene:75163. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

SHANK3,  H.sapiens
SH3 and multiple ankyrin repeat domains 3
1731 aa
SHANK3,  P.troglodytes
SH3 and multiple ankyrin repeat domains 3
1699 aa
LOC100430318,  M.mulatta
SH3 and multiple ankyrin repeat domains protein 3-like
1504 aa
SHANK3,  C.lupus
SH3 and multiple ankyrin repeat domains 3
1754 aa
SHANK3,  B.taurus
SH3 and multiple ankyrin repeat domains 3
1733 aa
Shank3,  M.musculus
SH3/ankyrin domain gene 3
1730 aa
Shank3,  R.norvegicus
SH3 and multiple ankyrin repeat domains 3
1740 aa
shank3,  X.tropicalis
SH3 and multiple ankyrin repeat domains 3
1906 aa
shank3b,  D.rerio
SH3 and multiple ankyrin repeat domains 3b
1643 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Autism, chromosome 22q13.3 deletion syndrome-related.
Chromosome 22q13.3 deletion syndrome.

Articles associated with genes and sequences of this homology group.

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Chon_Sulph_att (pfam06566)
  Chondroitin sulphate attachment domain.
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
Ank_4 (pfam13637)
  Ankyrin repeats (many copies).
ANK (cd00204)
  ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
SH3 (cl17036)
  Src Homology 3 domain superfamily.
Ank_2 (pfam12796)
  Ankyrin repeats (3 copies).
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
DUF535 (cl01128)
  Protein of unknown function (DUF535).
SAM_superfamily (cl15755)
  SAM (Sterile alpha motif ).
SH3 (cl17036)
  Src Homology 3 domain superfamily.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Shank3 includes H.sapiens SHANK3 and R.norvegicus Shank3.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (9 transcripts, 7 species)
Actinopterygii - bony fishes (3 transcripts, 2 species)
Amphibia - amphibians (1 transcript, 1 species)

Hydrozoa - hydrozoans (1 transcript, 1 species)

Trematoda - flatworms (1 transcript, 1 species)

Echinoidea - sea urchins (1 transcript, 1 species)




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