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Links from OMIM

HomoloGene:55648. Gene conserved in Bilateria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

LMX1B,  H.sapiens
LIM homeobox transcription factor 1, beta
402 aa
LMX1B,  P.troglodytes
LIM homeobox transcription factor 1, beta
623 aa
LMX1B,  C.lupus
LIM homeobox transcription factor 1, beta
487 aa
LMX1B,  B.taurus
LIM homeobox transcription factor 1, beta-like
802 aa
Lmx1b,  M.musculus
LIM homeobox transcription factor 1 beta
372 aa
Lmx1b,  R.norvegicus
LIM homeobox transcription factor 1 beta
402 aa
LMX1B,  G.gallus
LIM homeobox transcription factor 1, beta
377 aa
LOC100495130,  X.tropicalis
LIM homeobox transcription factor 1-beta.1-like
400 aa
lmx1bb,  D.rerio
LIM homeobox transcription factor 1, beta b
375 aa
lim-6,  C.elegans
316 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Nail-patella syndrome with open-angle glaucoma.
Nail-patella syndrome.

Articles associated with genes and sequences of this homology group.

LMX1B mutations cause hereditary FSGS without extrarenal involvement.
Boyer O, et al. J Am Soc Nephrol 24, 1216-22 (2013).
The signaling pathways of LMX1B and its role in glomerulosclerosis.
Zhou TB & Qin YH. J Recept Signal Transduct Res 32, 285-9 (2012).
Detection of genes regulated by Lmx1b during limb dorsalization.
Feenstra JM, et al. Dev Growth Differ 54, 451-62 (2012).
Association of transcription factor gene LMX1B with autism.
Thanseem I, et al. PLoS One 6, e23738 (2011).
Central serotonin neurons are required for arousal to CO2.
Buchanan GF & Richerson GB. Proc Natl Acad Sci U S A 107, 16354-9 (2010).
Nail-Patella Syndrome
Sweeney E, et al. (1993).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
LIM (cl02475)
  LIM is a small protein-protein interaction domain, containing two zinc fingers.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lmx1b includes H.sapiens LMX1B and R.norvegicus Lmx1b.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (8 transcripts, 8 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)

Insecta - insects (4 transcripts, 4 species)

Chromadorea - nematodes (1 transcript, 1 species)




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