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HomoloGene:7988. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

UBE3A,  H.sapiens
ubiquitin protein ligase E3A
NP_570854.1
872 aa
UBE3A,  P.troglodytes
ubiquitin protein ligase E3A
XP_001161311.1
872 aa
UBE3A,  M.mulatta
ubiquitin protein ligase E3A
XP_001108661.1
872 aa
UBE3A,  C.lupus
ubiquitin protein ligase E3A
XP_005618288.1
919 aa
UBE3A,  B.taurus
ubiquitin protein ligase E3A
NP_001091932.1
875 aa
Ube3a,  M.musculus
ubiquitin protein ligase E3A
NP_035798.2
870 aa
Ube3a,  R.norvegicus
ubiquitin protein ligase E3A
NP_001178766.1
868 aa
UBE3A,  G.gallus
ubiquitin protein ligase E3A
XP_004938531.1
880 aa
ube3a,  X.tropicalis
ubiquitin protein ligase E3A (human papilloma virus E6-associated protein, Angelman syndrome)
NP_001001213.1
856 aa
ube3a,  D.rerio
ubiquitin protein ligase E3A
NP_001007319.1
857 aa
Ube3a,  D.melanogaster
Ubiquitin protein ligase E3A
NP_648452.1
973 aa
AgaP_AGAP012366,  A.gambiae
AgaP_AGAP012366
XP_551819.3
916 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Angelman syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Screening of UBE3A gene in patients referred for Angelman Syndrome.
Tzagkaraki E, et al. Eur J Paediatr Neurol 17, 366-73 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HECTc (cl00077)
  HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ube3a includes H.sapiens UBE3A and R.norvegicus Ube3a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (23 transcripts, 15 species)
Actinopterygii - bony fishes (17 transcripts, 8 species)
Ascidiacea - tunicates (3 transcripts, 3 species)
Amniota - vertebrates (2 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (12 transcripts, 10 species)
Branchiopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Ascomycota
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Codonosigidae
Monosiga - choanoflagellates (1 transcript, 1 species)

 

 

 

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