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HomoloGene:20425. Gene conserved in Amniota Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

CDH3,  H.sapiens
cadherin 3, type 1, P-cadherin (placental)
829 aa
CDH3,  P.troglodytes
cadherin 3, type 1, P-cadherin (placental)
829 aa
CDH3,  C.lupus
cadherin 3, type 1, P-cadherin (placental)
833 aa
CDH3,  B.taurus
cadherin 3, type 1, P-cadherin (placental)
829 aa
Cdh3,  M.musculus
cadherin 3
822 aa
Cdh3,  R.norvegicus
cadherin 3
822 aa
CDH3,  G.gallus
cadherin 3, type 1, P-cadherin (placental)
667 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Hypotrichosis, congential, with juvenile macular dystrophy.

Articles associated with genes and sequences of this homology group.

Homozygous deletion in CDH3 and hypotrichosis with juvenile macular dystrophy.
Halford S, et al. Arch Ophthalmol 130, 1490-2 (2012).
A novel nonsense CDH3 mutation in hypotrichosis with juvenile macular dystrophy.
Avitan-Hersh E, et al. Int J Dermatol 51, 325-7 (2012).
In vivo therapeutic effect of CDH3/P-cadherin-targeting radioimmunotherapy.
Yoshioka H, et al. Cancer Immunol Immunother 61, 1211-20 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Cadherin (pfam00028)
  Cadherin domain.
Cadherin_C (pfam01049)
  Cadherin cytoplasmic region.
CA_like (cl15786)
  Cadherin repeat-like domain.
Cadherin_C (pfam01049)
  Cadherin cytoplasmic region.
Cadherin_pro (cl07391)
  Cadherin prodomain like.
CA_like (cl15786)
  Cadherin repeat-like domain.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Cdh3 includes H.sapiens CDH3 and R.norvegicus Cdh3.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (10 transcripts, 9 species)
Amphibia - amphibians (2 transcripts, 2 species)
Actinopterygii - bony fishes (1 transcript, 1 species)




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