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HomoloGene:22068. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

VPS13A,  H.sapiens
vacuolar protein sorting 13 homolog A (S. cerevisiae)
NP_150648.2
3174 aa
VPS13A,  P.troglodytes
vacuolar protein sorting 13 homolog A (S. cerevisiae)
XP_001148547.1
3174 aa
LOC705323,  M.mulatta
vacuolar protein sorting-associated protein 13A-like
XP_002808150.1
3174 aa
VPS13A,  C.lupus
vacuolar protein sorting 13 homolog A (S. cerevisiae)
XP_533522.3
3144 aa
VPS13A,  B.taurus
vacuolar protein sorting 13 homolog A (S. cerevisiae)
XP_002689716.3
1640 aa
Vps13a,  M.musculus
vacuolar protein sorting 13A (yeast)
NP_766616.2
3166 aa
Vps13a,  R.norvegicus
vacuolar protein sorting 13 homolog A (S. cerevisiae)
NP_001094445.2
3167 aa
VPS13A,  G.gallus
vacuolar protein sorting 13 homolog A (S. cerevisiae)
NP_001264765.1
3193 aa
vps13a,  X.tropicalis
vacuolar protein sorting 13 homolog A (S. cerevisiae)
XP_002937242.2
3181 aa
vps13a,  D.rerio
vacuolar protein sorting 13 homolog A (S. cerevisiae)
NP_001112365.1
3194 aa
Vps13,  D.melanogaster
Vacuolar protein sorting 13
NP_001260781.1
3321 aa
AgaP_AGAP005082,  A.gambiae
AgaP_AGAP005082
XP_558472.3
3290 aa
T08G11.1,  C.elegans
T08G11.1
NP_740900.1
3212 aa
VPS13,  S.cerevisiae
VPS13
NP_013060.1
3144 aa
KLLA0E00705g,  K.lactis
KLLA0E00705g
XP_453978.1
3124 aa
AGOS_ACL064C,  E.gossypii
AGOS_ACL064C
NP_983340.2
3116 aa
MGG_06537,  M.oryzae
MGG_06537
XP_003717004.1
3223 aa
NCU05837,  N.crassa
NCU05837
XP_960097.1
3209 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Choreoacanthocytosis.



Publications
Articles associated with genes and sequences of this homology group.

Novel pathogenic mutations and copy number variations in the VPS13A gene in patients with chorea-acanthocytosis.
Tomiyasu A, et al. Am J Med Genet B Neuropsychiatr Genet 156B, 620-31 (2011).
Chorea-Acanthocytosis
Velayos Baeza A, et al. (1993).
Choreoacanthocytosis in a Mexican family.
Ruiz-Sandoval JL, et al. Arch Neurol 64, 1661-4 (2007).
Chorein deficiency leads to upregulation of gephyrin and GABA(A) receptor.
Kurano Y, et al. Biochem Biophys Res Commun 351, 438-42 (2006).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ATG_C (pfam09333)
  ATG C terminal domain.
Chorein_N (pfam12624)
  N-terminal region of Chorein, a TM vesicle-mediated sorter.
DUF1162 (pfam06650)
  Protein of unknown function (DUF1162).
MRS6 (COG5043)
  Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion].
DUF1162 (pfam06650)
  Protein of unknown function (DUF1162).
Chorein_N (pfam12624)
  N-terminal region of Chorein, a TM vesicle-mediated sorter.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Vps13a includes H.sapiens VPS13A and R.norvegicus Vps13a.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (19 transcripts, 11 species)
Actinopterygii - bony fishes (15 transcripts, 7 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (15 transcripts, 9 species)
Arachnida - arachnids (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (4 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (2 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

 

 

 

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