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HomoloGene:160. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TBX5,  H.sapiens
T-box 5
NP_000183.2
518 aa
TBX5,  P.troglodytes
T-box 5
XP_001154140.2
518 aa
TBX5,  M.mulatta
T-box 5
XP_001111737.1
518 aa
TBX5,  C.lupus
T-box 5
XP_005636327.1
519 aa
TBX5,  B.taurus
T-box 5
NP_001179678.1
519 aa
Tbx5,  M.musculus
T-box 5
NP_035667.1
518 aa
Tbx5,  R.norvegicus
T-box 5
NP_001009964.1
517 aa
TBX5,  G.gallus
T-box 5
NP_989504.1
521 aa
tbx5,  X.tropicalis
T-box 5
NP_001185697.1
520 aa
tbx5a,  D.rerio
T-box 5a
NP_570990.1
485 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Holt-Oram syndrome.



Publications
Articles associated with genes and sequences of this homology group.

Hox genes regulate the onset of Tbx5 expression in the forelimb.
Minguillon C, et al. Development 139, 3180-8 (2012).
Holt-Oram Syndrome
McDermott DA, et al. (1993).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TBOX (cl00145)
  T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Tbx5 includes H.sapiens TBX5 and R.norvegicus Tbx5.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Actinopterygii - bony fishes (5 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

 

 

 

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