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HomoloGene:4551. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PRKAA2,  H.sapiens
protein kinase, AMP-activated, alpha 2 catalytic subunit
NP_006243.2
552 aa
PRKAA2,  P.troglodytes
protein kinase, AMP-activated, alpha 2 catalytic subunit
XP_001144587.1
552 aa
PRKAA2,  M.mulatta
protein kinase, AMP-activated, alpha 2 catalytic subunit
XP_002801614.1
491 aa
PRKAA2,  C.lupus
protein kinase, AMP-activated, alpha 2 catalytic subunit
XP_005620393.1
533 aa
PRKAA2,  B.taurus
protein kinase, AMP-activated, alpha 2 catalytic subunit
NP_001192534.1
552 aa
Prkaa2,  M.musculus
protein kinase, AMP-activated, alpha 2 catalytic subunit
NP_835279.2
552 aa
Prkaa2,  R.norvegicus
protein kinase, AMP-activated, alpha 2 catalytic subunit
NP_076481.1
552 aa
PRKAA2,  G.gallus
protein kinase, AMP-activated, alpha 2 catalytic subunit
NP_001034694.1
552 aa
prkaa2,  X.tropicalis
protein kinase, AMP-activated, alpha 2 catalytic subunit
NP_001135554.1
551 aa
prkaa2,  D.rerio
protein kinase, AMP-activated, alpha 2 catalytic subunit
XP_700831.4
553 aa
SNF1A,  D.melanogaster
SNF1A/AMP-activated protein kinase
NP_477313.1
582 aa
AgaP_AGAP002686,  A.gambiae
AgaP_AGAP002686
XP_312237.4
565 aa
aak-2,  C.elegans
aak-2
NP_510710.2
626 aa
SNF1,  S.cerevisiae
SNF1
NP_010765.3
633 aa
KLLA0A03806g,  K.lactis
KLLA0A03806g
XP_451166.1
602 aa
AGOS_AEL230W,  E.gossypii
AGOS_AEL230W
NP_984631.1
608 aa
ssp2,  S.pombe
ssp2
NP_588376.1
576 aa
MGG_00803,  M.oryzae
MGG_00803
XP_003718181.1
803 aa
NCU04566,  N.crassa
NCU04566
XP_958665.2
706 aa
Os03g0289100,  O.sativa
Os03g0289100
NP_001049790.1
508 aa
Os08g0484600,  O.sativa
Os08g0484600
NP_001062083.1
509 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

AMPK and insulin action--responses to ageing and high fat diet.
Frøsig C, et al. PLoS One 8, e62338 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
UBA_2 (pfam08587)
  Ubiquitin associated domain (UBA).
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
UBA_2 (pfam08587)
  Ubiquitin associated domain (UBA).
UBA (cl00153)
  Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been suggested that UBA domains are involved in conferring protein target specificity. The domain, a compact three helix bundle, has a conserved GFP-loop and the proline is thought to be critical for binding. The UBA domain is distinct from the conserved three helical domain seen in the N-terminus of EF-TS and eukaryotic NAC proteins.
AMPKA_C_like (cl17070)
  C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha subunit and similar domains.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Prkaa2 includes H.sapiens PRKAA2 and R.norvegicus Prkaa2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 10 species)
Aves - birds (3 transcripts, 3 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Actinopterygii - bony fishes (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (10 transcripts, 10 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Streptophyta
Liliopsida - monocots (20 transcripts, 9 species)
Eudicotyledons - eudicots (3 transcripts, 2 species)
Isoetopsida - club-mosses (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

 

 

 

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