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HomoloGene:21129. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ITGA3,  H.sapiens
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
NP_005492.1
1066 aa
ITGA3,  P.troglodytes
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
XP_511872.4
1041 aa
ITGA3,  M.mulatta
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
XP_001095554.1
1064 aa
ITGA3,  C.lupus
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
XP_548194.3
1066 aa
ITGA3,  B.taurus
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
XP_003587466.1
1065 aa
Itga3,  M.musculus
integrin alpha 3
NP_038593.1
1053 aa
Itga3,  R.norvegicus
integrin, alpha 3
XP_003750955.1
1052 aa
ITGA3,  G.gallus
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
NP_989477.1
1034 aa
LOC100494331,  X.tropicalis
integrin alpha-3-like
XP_004918665.1
1029 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
???.



Publications
Articles associated with genes and sequences of this homology group.

Adhesion proteins--an impact on skeletal myoblast differentiation.
Przewoźniak M, et al. PLoS One 8, e61760 (2013).
Integrin α3 mutations with kidney, lung, and skin disease.
Has C, et al. N Engl J Med 366, 1508-14 (2012).
α3β1 integrin promotes radiation-induced migration of meningioma cells.
Gogineni VR, et al. Int J Oncol 38, 1615-24 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Integrin_alpha2 (pfam08441)
  Integrin alpha.
VCBS (pfam13517)
  Family description.
FG-GAP (cl15299)
  FG-GAP repeat.
Integrin_alpha2 (pfam08441)
  Integrin alpha.
VCBS (cl15299)
  This domain of about 100 residues is found in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion (TIGR).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Itga3 includes H.sapiens ITGA3 and R.norvegicus Itga3.

 

 

 

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