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HomoloGene:1921. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

P2RX1,  H.sapiens
purinergic receptor P2X, ligand-gated ion channel, 1
NP_002549.1
399 aa
P2RX1,  P.troglodytes
purinergic receptor P2X, ligand-gated ion channel, 1
XP_511276.2
399 aa
P2RX1,  M.mulatta
purinergic receptor P2X, ligand-gated ion channel, 1
XP_001092205.1
399 aa
P2RX1,  C.lupus
purinergic receptor P2X, ligand-gated ion channel, 1
XP_548344.1
399 aa
P2RX1,  B.taurus
purinergic receptor P2X, ligand-gated ion channel, 1
NP_001192729.1
399 aa
P2rx1,  M.musculus
purinergic receptor P2X, ligand-gated ion channel, 1
NP_032797.3
399 aa
P2rx1,  R.norvegicus
purinergic receptor P2X, ligand-gated ion channel, 1
NP_037129.1
399 aa
P2RX1,  G.gallus
purinergic receptor P2X, ligand-gated ion channel, 1
NP_989850.1
392 aa
p2rx1,  X.tropicalis
purinergic receptor P2X, ligand-gated ion channel, 1
XP_002932325.2
410 aa
p2rx1,  D.rerio
purinergic receptor P2X, ligand-gated ion channel, 1
NP_945333.1
398 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Bleeding disorder due to P2RX1 defect.



Publications
Articles associated with genes and sequences of this homology group.

Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor.
Lörinczi É, et al. Proc Natl Acad Sci U S A 109, 11396-401 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
P2X_receptor (pfam00864)
  ATP P2X receptor.
P2X_receptor (cl02993)
  ATP P2X receptor.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus P2rx1 includes H.sapiens P2RX1 and R.norvegicus P2rx1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)
Actinopterygii - bony fishes (4 transcripts, 4 species)
Amniota - vertebrates (1 transcript, 1 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (1 transcript, 1 species)

 

 

 

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