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HomoloGene:1264. Gene conserved in Boreoeutheria

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	ASIP, H.sapiens agouti signaling protein			NP_001663.2 132 aa
	ASIP, P.troglodytes agouti signaling protein			NP_001129099.1 132 aa
	LOC709156, M.mulatta agouti-signaling protein-like			XP_001097667.1 58 aa
	ASIP, C.lupus agouti signaling protein			NP_001007264.1 131 aa
	ASIP, B.taurus agouti signaling protein			NP_996674.1 133 aa
	a, M.musculus nonagouti			NP_056585.2 131 aa
	Asip, R.norvegicus agouti signaling protein			NP_443211.1 131 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

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Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*H.sapiens*
MIM:611742 Skin/hair/eye pigmentation 9, dark/light hair.

Publications Articles associated with genes and sequences of this homology group.
Maternal cholestasis during pregnancy programs metabolic disease in offspring. Papacleovoulou G, et al. J Clin Invest 123, 3172-81 (2013).
Bisphenol a exposure disrupts genomic imprinting in the mouse. Susiarjo M, et al. PLoS Genet 9, e1003401 (2013).
Ellagic acid improves hepatic steatosis and serum lipid composition through reduction of serum resistin levels and transcriptional activation of hepatic ppara in obese, diabetic KK-A(y) mice. Yoshimura Y, et al. Biochem Biophys Res Commun 434, 486-91 (2013).
Inhibition of nuclear factor-κB activation in pancreatic β-cells has a protective effect on allogeneic pancreatic islet graft survival. Eldor R, et al. PLoS One 8, e56924 (2013).
Maternal exposure to bisphenol A and genistein has minimal effect on A(vy)/a offspring coat color but favors birth of agouti over nonagouti mice. Rosenfeld CS, et al. Proc Natl Acad Sci U S A 110, 537-42 (2013).
Specifying and sustaining pigmentation patterns in domestic and wild cats. Kaelin CB, et al. Science 337, 1536-41 (2012).
Variants at chromosome 20 (ASIP locus) and melanoma risk. Maccioni L, et al. Int J Cancer 132, 42-54 (2013).
Conserved distal promoter of the agouti signaling protein (ASIP) gene controls sexual dichromatism in chickens. Oribe E, et al. Gen Comp Endocrinol 177, 231-7 (2012).
Agouti revisited: transcript quantification of the ASIP gene in bovine tissues related to protein expression and localization. Albrecht E, et al. PLoS One 7, e35282 (2012).
Elaborate color patterns of individual chicken feathers may be formed by the agouti signaling protein. Yoshihara C, et al. Gen Comp Endocrinol 175, 495-9 (2012).
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Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
Agouti (cl04902) Agouti protein.
Agouti (cl04902) Agouti protein.

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:87853 Orthology group for M.musculus a includes H.sapiens ASIP and R.norvegicus Asip.

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