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HomoloGene:1789. Gene conserved in Euteleostomi

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	MC1R, H.sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)			NP_002377.4 317 aa
	MC1R, P.troglodytes melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)			NP_001009152.1 317 aa
	MC1R, C.lupus melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)			NP_001014304.1 317 aa
	MC1R, B.taurus melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)			NP_776533.1 317 aa
	Mc1r, M.musculus melanocortin 1 receptor			NP_032585.2 315 aa
	Mc1r, R.norvegicus melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)			XP_006255857.1 317 aa
	MC1R, G.gallus melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)			NP_001026633.1 314 aa
	mc1r, X.tropicalis melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)			XP_002937630.2 334 aa
	mc1r, D.rerio melanocortin 1 receptor			NP_851301.1 323 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*H.sapiens*
MIM:155555 Analgesia from kappa-opioid receptor agonist, female-specific.
MIM:155555 Blond/light brown hair and/or fair skin.
MIM:155555 Melanoma, susceptiblity to.
MIM:155555 Red hair/fair skin.
MIM:155555 UV-induced skin damage, susceptibility to.
MIM:203200 Oculocutaneous albinism, type II, modifier of.

Publications Articles associated with genes and sequences of this homology group.
Simultaneous purifying selection on the ancestral MC1R allele and positive selection on the melanoma-risk allele V60L in south Europeans. Martínez-Cadenas C, et al. Mol Biol Evol 30, 2654-65 (2013).
[Association study of MC1R gene polymorphisms with freckles in Chinese Han population from Chengdu]. Cao L, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 30, 352-6 (2013).
Melanoma risk associated with MC1R gene variants in Latvia and the functional analysis of rare variants. Ozola A, et al. Cancer Genet 206, 81-91 (2013).
Functional melanocortin 1 receptor Mc1r is not necessary for an inflammatory response to UV radiation in adult mouse skin. Wolnicka-Glubisz A, et al. Exp Dermatol 22, 226-8 (2013).
Variants in melanocortin 1 receptor gene contribute to risk of melanoma--a direct sequencing analysis in a Texas population. Guan X, et al. Pigment Cell Melanoma Res 26, 422-5 (2013).
MC1R gene mutation and its association with oculocutaneous albinism type (OCA) phenotype in a consanguineous Pakistani family. Saleha SB, et al. J Dermatol Sci 70, 68-70 (2013).
Anesthetic efficacy of the inferior alveolar nerve block in red-haired women. Droll B, et al. J Endod 38, 1564-9 (2012).
The melanocortin 1 receptor (MC1R) inhibits the inflammatory response in Raw 264.7 cells and atopic dermatitis (AD) mouse model. Chen W, et al. Mol Biol Rep 40, 1987-96 (2013).
MC1R variants predisposing to concomitant primary cutaneous melanoma in a monozygotic twin pair. Pellegrini C, et al. BMC Med Genet 13, 81 (2012).
Melanocortin 1 receptor (MC1R) variants in high melanoma risk patients are associated with specific dermoscopic ABCD features. Quint KD, et al. Acta Derm Venereol 92, 587-92 (2012).
See all (344)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
7tm_1 (pfam00001) 7 transmembrane receptor (rhodopsin family).
7tm_1 (pfam00001) 7 transmembrane receptor (rhodopsin family).

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:99456 Orthology group for M.musculus Mc1r includes H.sapiens MC1R.

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