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HomoloGene:5048. Gene conserved in Euteleostomi

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	PMEL, H.sapiens premelanosome protein			NP_001186983.1 668 aa
	PMEL, P.troglodytes premelanosome protein			XP_001169751.2 683 aa
	PMEL, M.mulatta premelanosome protein			XP_001113158.1 703 aa
	PMEL, C.lupus premelanosome protein			NP_001096686.1 658 aa
	PMEL, B.taurus premelanosome protein			NP_001073684.2 649 aa
	Pmel, M.musculus premelanosome protein			NP_068682.2 626 aa
	Pmel, R.norvegicus premelanosome protein			NP_001102199.1 418 aa
	PMEL, G.gallus premelanosome protein			NP_990443.2 763 aa
	pmel, X.tropicalis premelanosome protein			XP_004911936.1 765 aa
	pmelb, D.rerio premelanosome protein b			NP_001029090.2 616 aa
	pmela, D.rerio premelanosome protein a			NP_001038795.1 825 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Publications Articles associated with genes and sequences of this homology group.
[Detection of serum autoantibodies against premelanosome protein 17 increases in the vitiligo patients]. Hu L, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 29, 411-3, 417 (2013).
Critical residues in the PMEL/Pmel17 N-terminus direct the hierarchical assembly of melanosomal fibrils. Leonhardt RM, et al. Mol Biol Cell 24, 964-81 (2013).
The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma. Chen Y, et al. J Biol Chem 287, 24082-91 (2012).
Probing fibril dissolution of the repeat domain of a functional amyloid, Pmel17, on the microscopic and residue level. McGlinchey RP, et al. Biochemistry 50, 10567-9 (2011).
Mutations in or near the transmembrane domain alter PMEL amyloid formation from functional to pathogenic. Watt B, et al. PLoS Genet 7, e1002286 (2011).
Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation. Hellström AR, et al. PLoS Genet 7, e1002285 (2011).
Proprotein convertases process Pmel17 during secretion. Leonhardt RM, et al. J Biol Chem 286, 9321-37 (2011).
Effects of pH on aggregation kinetics of the repeat domain of a functional amyloid, Pmel17. Pfefferkorn CM, et al. Proc Natl Acad Sci U S A 107, 21447-52 (2010).
Genotype at the PMEL17 locus affects social and explorative behaviour in chickens. Karlsson AC, et al. Br Poult Sci 51, 170-7 (2010).
Endoplasmic reticulum export, subcellular distribution, and fibril formation by Pmel17 require an intact N-terminal domain junction. Leonhardt RM, et al. J Biol Chem 285, 16166-83 (2010).
See all (115)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
PKD (cl17457) polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.
HC2 (cl19298) Histone H1-like nucleoprotein HC2.

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:98301 Orthology group for M.musculus Pmel includes H.sapiens PMEL.

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