HomoloGene - NCBI

Warning: The NCBI web site requires JavaScript to function. more...

Links from Gene

HomoloGene:86654. Gene conserved in Tetrapoda

Download , Links

Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	F11, H.sapiens coagulation factor XI			NP_000119.1 625 aa
	F11, P.troglodytes coagulation factor XI			XP_001165847.1 625 aa
	F11, M.mulatta coagulation factor XI-like			XP_001090398.2 915 aa
	F11, C.lupus coagulation factor XI			NP_001128595.1 624 aa
	F11, B.taurus coagulation factor XI			NP_001008665.1 625 aa
	F11, M.musculus coagulation factor XI			NP_082342.1 624 aa
	F11, R.norvegicus coagulation factor XI			NP_001041313.1 556 aa
	F11, G.gallus coagulation factor XI			XP_420678.3 631 aa
	klkb1, X.tropicalis kallikrein B, plasma (Fletcher factor) 1			XP_004911242.1 629 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*H.sapiens*
MIM:264900 Factor XI deficiency, autosomal dominant.
MIM:264900 Factor XI deficiency, autosomal recessive.

Publications Articles associated with genes and sequences of this homology group.
Identification of a novel factor XI gene mutational event in a Dutch Caucasian family with inherited factor XI deficiency. Mulder R, et al. Thromb Haemost 109, 1183-5 (2013).
Type I mutation in the F11 gene is a third ancestral mutation which causes factor XI deficiency in Ashkenazi Jews. Peretz H, et al. J Thromb Haemost 11, 724-30 (2013).
Genetic analysis in FXI deficient patients from northwestern Italy: three novel and one recurrent mutation. Bicocchi MP, et al. Eur J Haematol 90, 351-3 (2013).
Factor XI is a substrate for oxidoreductases: enhanced activation of reduced FXI and its role in antiphospholipid syndrome thrombosis. Giannakopoulos B, et al. J Autoimmun 39, 121-9 (2012).
The F11 rs2289252 polymorphism is associated with FXI activity levels and APTT ratio in women with thrombosis. Lunghi B, et al. Thromb Res 130, 563-4 (2012).
High-resolution crystal structures of factor XIa coagulation factor in complex with nonbasic high-affinity synthetic inhibitors. Fradera X, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun 68, 404-8 (2012).
Identification of a novel F11 missense mutation (Ile463Ser) in a family with congenital factor XI deficiency. Tirefort Y, et al. Blood Coagul Fibrinolysis 23, 251-2 (2012).
Revisiting the molecular epidemiology of factor XI deficiency: nine new mutations and an original large 4qTer deletion in western Brittany (France). Guéguen P, et al. Thromb Haemost 107, 44-50 (2012).
A cluster of factor XI-deficient patients due to a new mutation (Ile 436 Lys) in northeastern Italy. Girolami A, et al. Eur J Haematol 88, 229-36 (2012).
Point mutations regarded as missense mutations cause splicing defects in the factor XI gene. Zucker M, et al. J Thromb Haemost 9, 1977-84 (2011).
See all (162)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
Tryp_SPc (cd00190) Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
RIC3 (pfam15361) Resistance to inhibitors of cholinesterase homologue 3.
PAN_APPLE (cl00112) PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:99481 Orthology group for M.musculus F11 includes H.sapiens F11 and R.norvegicus F11.

You are here: NCBI > Homology > HomoloGene