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HomoloGene:49153. Gene conserved in Boreoeutheria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

F8,  H.sapiens
coagulation factor VIII, procoagulant component
2351 aa
F8,  P.troglodytes
coagulation factor VIII, procoagulant component
2351 aa
LOC100424151,  M.mulatta
coagulation factor VIII-like
2152 aa
F8,  C.lupus
coagulation factor VIII, procoagulant component
2343 aa
F8,  B.taurus
coagulation factor VIII, procoagulant component
2323 aa
F8,  M.musculus
coagulation factor VIII
2319 aa
F8,  R.norvegicus
coagulation factor VIII, procoagulant component
2258 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.

Hemophilia A.

Articles associated with genes and sequences of this homology group.

The canine factor VIII cDNA and 5' flanking sequence.
Cameron C, et al. Thromb Haemost 79, 317-22 (1998).
Mutations in the FVIII gene in seven families with mild haemophilia A.
Mazurier C, et al. Br J Haematol 96, 426-7 (1997).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FA58C (cl19067)
  Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
Cupredoxin (cl19115)
  Cupredoxin superfamily.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus F8 includes H.sapiens F8 and R.norvegicus F8.




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