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HomoloGene:49153. Gene conserved in Boreoeutheria

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	F8, H.sapiens coagulation factor VIII, procoagulant component			NP_000123.1 2351 aa
	F8, P.troglodytes coagulation factor VIII, procoagulant component			XP_003317837.1 2351 aa
	LOC100424151, M.mulatta coagulation factor VIII-like			XP_002806506.1 2152 aa
	F8, C.lupus coagulation factor VIII, procoagulant component			NP_001003212.1 2343 aa
	F8, B.taurus coagulation factor VIII, procoagulant component			NP_001138980.1 2323 aa
	F8, M.musculus coagulation factor VIII			NP_032003.2 2319 aa
	F8, R.norvegicus coagulation factor VIII, procoagulant component			NP_899160.1 2258 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

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Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*H.sapiens*
MIM:306700 Hemophilia A.

Publications Articles associated with genes and sequences of this homology group.
The canine factor VIII cDNA and 5' flanking sequence. Cameron C, et al. Thromb Haemost 79, 317-22 (1998).
Protein truncation test: detection of severe haemophilia a mutation and analysis of factor VIII transcripts. Maugard C, et al. Hum Mutat 11, 18-22 (1998).
Mutational analysis of ectopic factor VIII transcripts from hemophilia A patients: identification of cryptic splice site, exon skipping and novel point mutations. Tavassoli K, et al. Hum Genet 100, 508-11 (1997).
Factor VIII gene analysis in Japanese CRM-positive and CRM-reduced haemophilia A patients by single-strand conformation polymorphism. Morichika S, et al. Br J Haematol 98, 901-6 (1997).
A molecular model for the triplicated A domains of human factor VIII based on the crystal structure of human ceruloplasmin. Pemberton S, et al. Blood 89, 2413-21 (1997).
Mutations in the FVIII gene in seven families with mild haemophilia A. Mazurier C, et al. Br J Haematol 96, 426-7 (1997).
Further characterization of factor VIII-deficient mice created by gene targeting: RNA and protein studies. Bi L, et al. Blood 88, 3446-50 (1996).
Mutations in a subgroup of patients with mild haemophilia A and a familial discrepancy between the one-stage and two-stage factor VIII:C methods. Rudzki Z, et al. Br J Haematol 94, 400-6 (1996).
Analysis of the BglI restriction fragment length polymorphism in the human factor VIII gene using "virtual PCR"--a novel approach employing the polymerase chain reaction in the absence of sequence information for the locus. Bowen DJ & Hampton KK. Hum Genet 98, 219-22 (1996).
Characterization of the factor VIII defect in 147 patients with sporadic hemophilia A: family studies indicate a mutation type-dependent sex ratio of mutation frequencies. Becker J, et al. Am J Hum Genet 58, 657-70 (1996).
See all (100)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
FA58C (cl19067) Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
Cupredoxin (cl19115) Cupredoxin superfamily.

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:88383 Orthology group for M.musculus F8 includes H.sapiens F8 and R.norvegicus F8.

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