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HomoloGene:37289. Gene conserved in Opisthokonta

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	SLC3A1, H.sapiens solute carrier family 3 (amino acid transporter heavy chain), member 1			NP_000332.2 685 aa
	SLC3A1, P.troglodytes solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1			XP_515443.2 685 aa
	SLC3A1, M.mulatta solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1			XP_001112327.2 647 aa
	SLC3A1, C.lupus solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1			NP_001003109.1 700 aa
	SLC3A1, B.taurus solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1			NP_001029805.1 685 aa
	Slc3a1, M.musculus solute carrier family 3, member 1			NP_033231.2 685 aa
	Slc3a1, R.norvegicus solute carrier family 3, member 1			NP_058912.1 683 aa
	SLC3A1, G.gallus solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1			XP_426125.3 684 aa
	slc3a1, X.tropicalis solute carrier family 3 (amino acid transporter heavy chain), member 1			NP_001072903.1 693 aa
	slc3a1, D.rerio solute carrier family 3 (cystine, dibasic and neutral amino acid transporters, activator of cystine, dibasic and neutral amino acid transport), member 1			XP_685969.3 674 aa
	Mal-B1, D.melanogaster Maltase B1			NP_609522.1 584 aa
	Mal-B2, D.melanogaster Maltase B2			NP_609523.2 564 aa
	AgaP_AGAP008965, A.gambiae AgaP_AGAP008965			XP_319713.4 683 aa
	MGG_07547, M.oryzae MGG_07547			XP_003711461.1 622 aa
	NCU06523, N.crassa NCU06523			XP_961795.1 608 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

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Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*H.sapiens*
MIM:220100 Cystinuria.
MIM:606407 Homozygous 2p16 deletion syndrome.

Publications Articles associated with genes and sequences of this homology group.
[ATR1 gene polymorphism in patients with hypertrophic cardiomyopathy and hypertensive heart]. Smirnova MD, et al. Kardiologiia 50, 41-4 (2010).
Distinct classes of trafficking rBAT mutants cause the type I cystinuria phenotype. Bartoccioni P, et al. Hum Mol Genet 17, 1845-54 (2008).
Analysis of a 1-year-old cystinuric patient with recurrent renal stones. Tanzer F, et al. Int J Urol 13, 1347-9 (2006).
Gene symbol: SLC3A1. Disease: cystinuria. Nunes V, et al. Hum Genet 116, 232 (2005).
Gene symbol: SLC3A1. Disease: cystinuria. Nunes V, et al. Hum Genet 116, 232 (2005).
Gene symbol: SLC3A1. Disease: cystinuria. Nunes V, et al. Hum Genet 116, 231 (2005).
Identification of novel SLC3A1 gene mutations in Spanish cystinuria families and association with clinical phenotypes. Guillén M, et al. Clin Genet 67, 240-51 (2005).
Cystinuria-specific rBAT(R365W) mutation reveals two translocation pathways in the amino acid transporter rBAT-b0,+AT. Pineda M, et al. Biochem J 377, 665-74 (2004).
Genomic and functional investigations of mutations of the SLC3A1 gene in cystinuria. Lahme S, et al. Urol Int 69, 207-11 (2002).
Apical heterodimeric cystine and cationic amino acid transporter expressed in MDCK cells. Bauch C & Verrey F. Am J Physiol Renal Physiol 283, F181-9 (2002).
See all (69)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
AmyAc_family (cl07893) Alpha amylase catalytic domain family.

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:1195264 Orthology group for M.musculus Slc3a1 includes H.sapiens SLC3A1 and R.norvegicus Slc3a1.

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