Display Settings:

Format

Send to:

Choose Destination
HomoloGene:68371. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PHOX2B,  H.sapiens
paired-like homeobox 2b
NP_003915.2
314 aa
PHOX2B,  P.troglodytes
paired-like homeobox 2b
XP_001149518.1
314 aa
PHOX2B,  M.mulatta
paired-like homeobox 2b
XP_001098028.1
314 aa
PHOX2B,  C.lupus
paired-like homeobox 2b
XP_852840.1
314 aa
Phox2b,  M.musculus
paired-like homeobox 2b
NP_032914.1
314 aa
PHOX2B,  G.gallus
paired-like homeobox 2b
XP_001234151.2
250 aa
phox2b,  X.tropicalis
paired-like homeobox 2b
NP_001116492.1
293 aa
phox2bb,  D.rerio
paired-like homeobox 2bb
NP_001014818.1
284 aa
LOC101885818,  D.rerio
paired mesoderm homeobox protein 2B-like
XP_005157278.1
284 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Hirschsprung disease, short-segment.
Central hypoventilation syndrome, congenital.
Neuroblastoma.



Publications
Articles associated with genes and sequences of this homology group.

Contributions of PHOX2B in the pathogenesis of Hirschsprung disease.
Fernández RM, et al. PLoS One 8, e54043 (2013).
Phox2b influences the development of a caudal dopaminergic subset.
Hoekstra EJ, et al. PLoS One 7, e52118 (2012).
[Late onset Ondine syndrome: literature review on a case report].
Butin M, et al. Arch Pediatr 19, 1205-7 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Phox2b includes H.sapiens PHOX2B and R.norvegicus Phox2b.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (4 transcripts, 3 species)
Actinopterygii - bony fishes (3 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

 

 

 

Support Center