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HomoloGene:56150. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ATP2B2,  H.sapiens
ATPase, Ca++ transporting, plasma membrane 2
NP_001001331.1
1243 aa
ATP2B2,  P.troglodytes
ATPase, Ca++ transporting, plasma membrane 2
XP_001151685.2
1209 aa
ATP2B2,  C.lupus
ATPase, Ca++ transporting, plasma membrane 2
XP_005632215.1
1243 aa
ATP2B2,  B.taurus
ATPase, Ca++ transporting, plasma membrane 2
NP_001178174.1
1198 aa
Atp2b2,  M.musculus
ATPase, Ca++ transporting, plasma membrane 2
NP_033853.1
1198 aa
Atp2b2,  R.norvegicus
ATPase, Ca++ transporting, plasma membrane 2
NP_036640.1
1198 aa
ATP2B2,  G.gallus
ATPase, Ca++ transporting, plasma membrane 2
XP_001231642.1
1245 aa
atp2b2,  X.tropicalis
ATPase, Ca++ transporting, plasma membrane 2
XP_002934276.2
1257 aa
atp2b2,  D.rerio
ATPase, Ca++ transporting, plasma membrane 2
NP_001116710.1
1253 aa
PMC1,  S.cerevisiae
PMC1
NP_011509.1
1173 aa
KLLA0A08910g,  K.lactis
KLLA0A08910g
XP_451391.1
1280 aa
AGOS_AFL011W,  E.gossypii
AGOS_AFL011W
NP_985537.1
1242 aa
MGG_02487,  M.oryzae
MGG_02487
XP_003709283.1
1447 aa
NCU04736,  N.crassa
NCU04736
XP_960371.2
1449 aa
Os02g0176700,  O.sativa
Os02g0176700
NP_001046064.2
1029 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Deafness, autosomal recessive 12, modifier of.



Publications
Articles associated with genes and sequences of this homology group.

Two ENU-induced alleles of Atp2b2 cause deafness in mice.
Carpinelli MR, et al. PLoS One 8, e67479 (2013).
Apical localization of PMCA2w/b is enhanced in terminally polarized MDCK cells.
Antalffy G, et al. Biochem Biophys Res Commun 410, 322-7 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
HAD_like (cd01427)
  Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
ATP_Ca_trans_C (pfam12424)
  Plasma membrane calcium transporter ATPase C terminal.
Cation_ATPase_N (pfam00690)
  Cation transporter/ATPase, N-terminus.
CaATP_NAI (pfam12515)
  Ca2+-ATPase N terminal autoinhibitory domain.
HAD_like (cl11391)
  Haloacid Dehalogenase-like Hydrolases.
Pglycolate_arch (TIGR01487)
  phosphoglycolate phosphatase, TA0175-type.
E1-E2_ATPase (pfam00122)
  E1-E2 ATPase.
Cation_ATPase_C (pfam00689)
  Cation transporting ATPase, C-terminus.
Hydrolase_like2 (pfam13246)
  Putative hydrolase of sodium-potassium ATPase alpha subunit.
COG4087 (COG4087)
  Soluble P-type ATPase [General function prediction only].
HAD_like (cl17915)
  Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
E1-E2_ATPase (pfam00122)
  E1-E2 ATPase.
Cation_ATPase_C (pfam00689)
  Cation transporting ATPase, C-terminus.
ATP_Ca_trans_C (pfam12424)
  Plasma membrane calcium transporter ATPase C terminal.
Hydrolase_like2 (pfam13246)
  Putative hydrolase of sodium-potassium ATPase alpha subunit.
Cation_ATPase_N (cl02930)
  Cation transporter/ATPase, N-terminus.
HAD (cl19137)
  haloacid dehalogenase-like hydrolase.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Atp2b2 includes H.sapiens ATP2B2 and R.norvegicus Atp2b2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Streptophyta
Eudicotyledons - eudicots (57 transcripts, 26 species)
Liliopsida - monocots (24 transcripts, 9 species)

Chordata
Mammalia - mammals (16 transcripts, 10 species)
Actinopterygii - bony fishes (12 transcripts, 5 species)
Ascidiacea - tunicates (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 1 species)

Arthropoda
Arachnida - arachnids (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Porifera
Demospongiae - sponges (1 transcript, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (4 transcripts, 3 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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