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HomoloGene:474. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

IL6R,  H.sapiens
interleukin 6 receptor
NP_000556.1
468 aa
IL6R,  P.troglodytes
interleukin 6 receptor
XP_524889.3
468 aa
IL6R,  M.mulatta
interleukin 6 receptor
XP_001114404.1
468 aa
IL6R,  C.lupus
interleukin 6 receptor
XP_855105.1
468 aa
IL6R,  B.taurus
interleukin 6 receptor
NP_001104255.1
464 aa
Il6ra,  M.musculus
interleukin 6 receptor, alpha
NP_034689.2
460 aa
Il6r,  R.norvegicus
interleukin 6 receptor
NP_058716.2
462 aa
il6r,  X.tropicalis
interleukin 6 receptor
XP_002943407.2
234 aa
il6r,  D.rerio
interleukin 6 receptor
NP_001107790.1
580 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis.
Esparza-Gordillo J, et al. J Allergy Clin Immunol 132, 371-7 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
IGc2 (smart00408)
  Immunoglobulin C-2 Type.
IG_like (smart00410)
  Immunoglobulin like.
IL6Ra-bind (pfam09240)
  Interleukin-6 receptor alpha chain, binding.
IL6Ra-bind (pfam09240)
  Interleukin-6 receptor alpha chain, binding.
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Il6ra includes H.sapiens IL6R and R.norvegicus Il6ra.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (6 transcripts, 6 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)

 

 

 

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