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HomoloGene:3947. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

SIX3,  H.sapiens
SIX homeobox 3
332 aa
SIX3,  P.troglodytes
SIX homeobox 3
282 aa
SIX3,  C.lupus
SIX homeobox 3
580 aa
SIX3,  B.taurus
SIX homeobox 3
328 aa
Six3,  M.musculus
sine oculis-related homeobox 3
333 aa
Six3,  R.norvegicus
SIX homeobox 3
337 aa
SIX3,  G.gallus
SIX homeobox 3
314 aa
six3,  X.tropicalis
SIX homeobox 3
295 aa
six3a,  D.rerio
sine oculis homeobox homolog 3a
294 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Phenotypic information for the genes in this entry imported from model organism databases.


Articles associated with genes and sequences of this homology group.

Absence of SIX3 mutations in patients with congenital hypopituitarism.
Gaston-Massuet C, et al. Am J Med Genet A 149A, 2874-6 (2009).
A novel SIX3 mutation segregates with holoprosencephaly in a large family.
Solomon BD, et al. Am J Med Genet A 149A, 919-25 (2009).
Six3 controls the neural progenitor status in the murine CNS.
Appolloni I, et al. Cereb Cortex 18, 553-62 (2008).
Regulation of the human SIX3 gene promoter.
Lengler J & Graw J. Biochem Biophys Res Commun 287, 372-6 (2001).
Sequence and location of SIX3, a homeobox gene expressed in the human eye.
Leppert GS, et al. Ophthalmic Genet 20, 7-21 (1999).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Six3 includes H.sapiens SIX3 and R.norvegicus Six3.

Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Mammalia - mammals (7 transcripts, 5 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 1 species)
Aves - birds (2 transcripts, 2 species)




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