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HomoloGene:37942. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TAF1,  H.sapiens
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
NP_004597.2
1893 aa
TAF1,  M.mulatta
transcription initiation factor TFIID subunit 1-like
XP_002808585.1
1839 aa
TAF1,  C.lupus
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
XP_005641531.1
1926 aa
TAF1,  B.taurus
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
XP_005228102.1
1910 aa
Taf1,  M.musculus
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor
NP_001074477.1
1902 aa
Taf1,  R.norvegicus
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor
NP_001178652.1
1893 aa
TAF1,  G.gallus
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
XP_420198.4
1905 aa
taf1,  X.tropicalis
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
XP_002934954.2
1846 aa
taf1,  D.rerio
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor
NP_001038250.1
1947 aa
Taf1,  D.melanogaster
TBP-associated factor 1
NP_996159.1
2098 aa
AgaP_AGAP003882,  A.gambiae
AgaP_AGAP003882
XP_308108.5
2003 aa
taf-1,  C.elegans
taf-1
NP_493426.2
1744 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Dystonia-Parkinsonism, X-linked.



Publications
Articles associated with genes and sequences of this homology group.

Holo-TFIID controls the magnitude of a transcription burst and fine-tuning of transcription.
Pennington KL, et al. Proc Natl Acad Sci U S A 110, 7678-83 (2013).
X-Linked Dystonia-Parkinsonism
Evidente VGH, et al. (1993).
The monogenic primary dystonias.
Müller U. Brain 132, 2005-25 (2009).
Immunohistochemical study of TAFII250 in the rat laryngeal nervous system.
Okano H, et al. Histol Histopathol 20, 1029-35 (2005).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TBP-binding (pfam09247)
  TATA box-binding protein binding.
DUF3591 (pfam12157)
  Protein of unknown function (DUF3591).
Bromodomain (cl02556)
  Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
DUF3591 (cl15417)
  Protein of unknown function (DUF3591).
DUF3591 (pfam12157)
  Protein of unknown function (DUF3591).
zf-CCHC_6 (pfam15288)
  Zinc knuckle.
Bromodomain (cl02556)
  Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Taf1 includes H.sapiens TAF1 and R.norvegicus Taf1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 7 species)
Actinopterygii - bony fishes (9 transcripts, 6 species)
Aves - birds (4 transcripts, 2 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (6 transcripts, 6 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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