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HomoloGene:3483. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

LRAT,  H.sapiens
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
NP_004735.2
230 aa
LRAT,  P.troglodytes
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
XP_526710.2
230 aa
LRAT,  M.mulatta
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
XP_001092118.1
230 aa
LRAT,  C.lupus
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
XP_539777.2
230 aa
LRAT,  B.taurus
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
NP_803469.1
230 aa
Lrat,  M.musculus
lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
NP_076113.1
231 aa
Lrat,  R.norvegicus
lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)
NP_071616.1
231 aa
LRAT,  G.gallus
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
XP_420371.2
232 aa
lrat,  X.tropicalis
lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
NP_989141.1
228 aa
LOC100485002,  X.tropicalis
lecithin retinol acyltransferase-like
XP_002933533.1
227 aa
lrata,  D.rerio
lecithin retinol acyltransferase a (phosphatidylcholine--retinol O-acyltransferase a)
NP_001191060.1
225 aa
lratb,  D.rerio
lecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)
XP_001921190.2
226 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Retinal dystrophy, early-onset severe.



Publications
Articles associated with genes and sequences of this homology group.

Hepatic retinoid stores are required for normal liver regeneration.
Shmarakov IO, et al. J Lipid Res 54, 893-908 (2013).
A homozygous frameshift mutation in LRAT causes retinitis punctata albescens.
Littink KW, et al. Ophthalmology 119, 1899-906 (2012).
An acyl-covalent enzyme intermediate of lecithin:retinol acyltransferase.
Golczak M & Palczewski K. J Biol Chem 285, 29217-22 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LRAT (pfam04970)
  Lecithin retinol acyltransferase.
LRAT (pfam04970)
  Lecithin retinol acyltransferase.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Lrat includes H.sapiens LRAT and R.norvegicus Lrat.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (6 transcripts, 6 species)
Actinopterygii - bony fishes (6 transcripts, 4 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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