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HomoloGene:175. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PDX1,  H.sapiens
pancreatic and duodenal homeobox 1
NP_000200.1
283 aa
PDX1,  P.troglodytes
pancreatic and duodenal homeobox 1
NP_001074947.1
283 aa
PDX1,  M.mulatta
pancreas/duodenum homeobox protein 1-like
XP_001096758.1
281 aa
PDX1,  C.lupus
pancreatic and duodenal homeobox 1
XP_543155.3
282 aa
PDX1,  B.taurus
pancreatic and duodenal homeobox 1
NP_001179065.1
285 aa
Pdx1,  M.musculus
pancreatic and duodenal homeobox 1
NP_032840.1
284 aa
Pdx1,  R.norvegicus
pancreatic and duodenal homeobox 1
NP_074043.3
283 aa
PDX1,  G.gallus
pancreatic and duodenal homeobox 1
XP_001234636.2
273 aa
pdx1,  X.tropicalis
pancreatic and duodenal homeobox 1
XP_002934065.1
271 aa
pdx1,  D.rerio
pancreatic and duodenal homeobox 1
NP_571518.2
246 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Diabetes mellitus, type II, susceptibility to.
Pancreatic agenesis.
MODY, type IV.



Publications
Articles associated with genes and sequences of this homology group.

Binding polymorphism in the DNA bound state of the Pdx1 homeodomain.
Babin V, et al. PLoS Comput Biol 9, e1003160 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
homeodomain (cl00084)
  Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pdx1 includes H.sapiens PDX1 and R.norvegicus Pdx1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 7 species)
Actinopterygii - bony fishes (2 transcripts, 2 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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