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HomoloGene:1738. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

LIMK1,  H.sapiens
LIM domain kinase 1
NP_002305.1
647 aa
LIMK1,  P.troglodytes
LIM domain kinase 1
XP_001148746.2
647 aa
LIMK1,  M.mulatta
LIM domain kinase 1
XP_002803600.1
677 aa
LIMK1,  C.lupus
LIM domain kinase 1
XP_849646.1
647 aa
LIMK1,  B.taurus
LIM domain kinase 1
NP_001193833.1
647 aa
Limk1,  M.musculus
LIM-domain containing, protein kinase
NP_034847.1
647 aa
Limk1,  R.norvegicus
LIM domain kinase 1
NP_113915.2
647 aa
LIMK1,  G.gallus
LIM domain kinase 1
NP_989462.1
662 aa
limk1,  X.tropicalis
LIM domain kinase 1
NP_001072900.1
615 aa
limk1a,  D.rerio
LIM domain kinase 1a
NP_001036156.1
648 aa
LIMK1,  D.melanogaster
LIM-kinase1
NP_511139.2
1257 aa
AgaP_AGAP011710,  A.gambiae
AgaP_AGAP011710
XP_320802.4
777 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

LIM kinase 1 deficient mice have reduced bone mass.
Kawano T, et al. Bone 52, 70-82 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
TyrKc (smart00219)
  Tyrosine kinase, catalytic domain.
STYKc (smart00221)
  Protein kinase; unclassified specificity.
S_TKc (smart00220)
  Serine/Threonine protein kinases, catalytic domain.
LIM (cl02475)
  LIM is a small protein-protein interaction domain, containing two zinc fingers.
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
LIM (cl02475)
  LIM is a small protein-protein interaction domain, containing two zinc fingers.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Limk1 includes H.sapiens LIMK1 and R.norvegicus Limk1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (9 transcripts, 8 species)
Actinopterygii - bony fishes (7 transcripts, 4 species)
Amphibia - amphibians (2 transcripts, 2 species)
Aves - birds (1 transcript, 1 species)

Arthropoda
Insecta - insects (4 transcripts, 4 species)
Arachnida - arachnids (1 transcript, 1 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Platyhelminthes
Turbellaria - flatworms (1 transcript, 1 species)

 

 

 

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