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HomoloGene:15850. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

NIPBL,  H.sapiens
Nipped-B homolog (Drosophila)
NP_597677.2
2804 aa
NIPBL,  P.troglodytes
Nipped-B homolog (Drosophila)
XP_001146090.1
2804 aa
NIPBL,  M.mulatta
Nipped-B homolog (Drosophila)
XP_001096575.1
2804 aa
NIPBL,  C.lupus
Nipped-B homolog (Drosophila)
XP_005619439.1
2804 aa
NIPBL,  B.taurus
Nipped-B homolog (Drosophila)
NP_001193513.1
2804 aa
Nipbl,  M.musculus
Nipped-B homolog (Drosophila)
NP_081983.2
2798 aa
Nipbl,  R.norvegicus
Nipped-B homolog (Drosophila)
XP_003749266.1
2798 aa
LOC427439,  G.gallus
Nipped-B homolog-like
XP_425012.3
2783 aa
LOC427025,  G.gallus
Nipped-B homolog-like
NP_001244277.1
2769 aa
nipbl,  X.tropicalis
Nipped-B homolog
XP_002938229.2
1771 aa
nipblb,  D.rerio
nipped-b homolog b (Drosophila)
NP_001154919.2
2876 aa
Nipped-B,  D.melanogaster
Nipped-B
NP_001163052.1
2053 aa
AgaP_AGAP009290,  A.gambiae
AgaP_AGAP009290
XP_320088.4
2071 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cornelia de Lange syndrome 1.



Publications
Articles associated with genes and sequences of this homology group.

High rate of mosaicism in individuals with Cornelia de Lange syndrome.
Huisman SA, et al. J Med Genet 50, 339-44 (2013).
Mutation analysis in Chinese patients with Cornelia de Lange syndrome.
Zhong Q, et al. Genet Test Mol Biomarkers 16, 1130-4 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PHA03151 (PHA03151)
  hypothetical protein; Provisional.
TFIIFa (cl15395)
  Transcription initiation factor IIF, alpha subunit, N-terminal region of RAP74. Subunit of transcription initiation complex involved in initiation, elongation and promoter escape.Tetramer of 2 alpha and 2 beta TFIIF subunits interacts directly with RNA ...
Cohesin_HEAT (pfam12765)
  HEAT repeat associated with sister chromatid cohesion.
AF-4 (pfam05110)
  AF-4 proto-oncoprotein.
DUF1509 (pfam07420)
  Protein of unknown function (DUF1509).
Nipped-B_C (pfam12830)
  Sister chromatid cohesion C-terminus.
VirD2 (COG3843)
  Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion].
Neuromodulin (pfam06614)
  Neuromodulin.
MFMR (pfam07777)
  G-box binding protein MFMR.
DUF1777 (pfam08648)
  Protein of unknown function (DUF1777).
CAF-1_p150 (pfam11600)
  Chromatin assembly factor 1 complex p150 subunit, N-terminal.
Cohesin_HEAT (pfam12765)
  HEAT repeat associated with sister chromatid cohesion.
Nipped-B_C (pfam12830)
  Sister chromatid cohesion C-terminus.
PRP38_assoc (pfam12871)
  Pre-mRNA-splicing factor 38-associated hydrophilic C-term.
TrkH (cl17365)
  Cation transport protein.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nipbl includes H.sapiens NIPBL and R.norvegicus NIPBL.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (30 transcripts, 15 species)
Actinopterygii - bony fishes (30 transcripts, 10 species)
Aves - birds (8 transcripts, 2 species)
Amphibia - amphibians (6 transcripts, 2 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Cephalochordata - lancelets (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 8 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (5 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Cnidaria
Anthozoa - anthozoans (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (10 transcripts, 10 species)
Liliopsida - monocots (9 transcripts, 7 species)

 

 

 

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