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HomoloGene:13786. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SMC1B,  H.sapiens
structural maintenance of chromosomes 1B
NP_683515.3
1235 aa
SMC1B,  P.troglodytes
structural maintenance of chromosomes 1B
XP_515195.2
1235 aa
SMC1B,  M.mulatta
structural maintenance of chromosomes 1B
XP_001109647.1
1234 aa
SMC1B,  C.lupus
structural maintenance of chromosomes 1B
XP_538328.2
1235 aa
SMC1B,  B.taurus
structural maintenance of chromosomes 1B
XP_002688026.1
1235 aa
Smc1b,  M.musculus
structural maintenance of chromosomes 1B
NP_536718.1
1248 aa
Smc1b,  R.norvegicus
structural maintenance of chromosomes 1B
NP_001123970.1
1247 aa
SMC1B,  G.gallus
structural maintenance of chromosomes 1B
XP_416467.2
1243 aa
smc1b,  X.tropicalis
structural maintenance of chromosomes 1B
NP_001265278.1
1228 aa
smc1b,  D.rerio
structural maintenance of chromosomes 1B
XP_001334257.2
1234 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

A spontaneous smc1b mutation causes cohesin protein dysfunction and sterility in mice.
Takabayashi S, et al. Exp Biol Med (Maywood) 234, 994-1001 (2009).
Mutagenesis as an unbiased approach to identify novel contraceptive targets.
Handel MA, et al. Mol Cell Endocrinol 250, 201-5 (2006).
Cohesin SMC1beta protects telomeres in meiocytes.
Adelfalk C, et al. J Cell Biol 187, 185-99 (2009).
Cohesin component dynamics during meiotic prophase I in mammalian oocytes.
Prieto I, et al. Chromosome Res 12, 197-213 (2004).
Identification and molecular characterization of the mammalian α-kleisin RAD21L.
Gutiérrez-Caballero C, et al. Cell Cycle 10, 1477-87 (2011).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
ABC_ATPase (cl17201)
  ATP-binding cassette transporter nucleotide-binding domain.
SMC_hinge (cl05797)
  This family represents the hinge region of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that the precise structure of it is an essential determinant of the specificity of the DNA-protein interaction.
ABC_ATPase (cl17201)
  ATP-binding cassette transporter nucleotide-binding domain.
DUF342 (cl19219)
  Protein of unknown function (DUF342).



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Smc1b includes H.sapiens SMC1B and R.norvegicus Smc1b.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (11 transcripts, 8 species)
Actinopterygii - bony fishes (3 transcripts, 3 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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