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HomoloGene:1053. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

DYNC1H1,  H.sapiens
dynein, cytoplasmic 1, heavy chain 1
NP_001367.2
4646 aa
DYNC1H1,  P.troglodytes
dynein, cytoplasmic 1, heavy chain 1
XP_003314564.1
4545 aa
LOC718989,  M.mulatta
cytoplasmic dynein 1 heavy chain 1-like
XP_001112455.2
4524 aa
DYNC1H1,  C.lupus
dynein, cytoplasmic 1, heavy chain 1
XP_537556.2
4646 aa
DYNC1H1,  B.taurus
dynein, cytoplasmic 1, heavy chain 1
NP_001193067.1
4645 aa
Dync1h1,  M.musculus
dynein cytoplasmic 1 heavy chain 1
NP_084514.2
4644 aa
Dync1h1,  R.norvegicus
dynein cytoplasmic 1 heavy chain 1
NP_062099.3
4644 aa
DYNC1H1,  G.gallus
dynein, cytoplasmic 1, heavy chain 1
XP_421371.3
4577 aa
dync1h1,  D.rerio
dynein, cytoplasmic 1, heavy chain 1
NP_001036210.1
4643 aa
Dhc64C,  D.melanogaster
Dynein heavy chain 64C
NP_523929.2
4639 aa
AgaP_AGAP002015,  A.gambiae
AgaP_AGAP002015
XP_003436004.1
4670 aa
dhc-1,  C.elegans
dhc-1
NP_491363.1
4568 aa
MGG_11205,  M.oryzae
MGG_11205
XP_003714413.1
4353 aa
NCU06976,  N.crassa
NCU06976
XP_962616.1
4367 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Reconstitution of the human cytoplasmic dynein complex.
Trokter M, et al. Proc Natl Acad Sci U S A 109, 20895-900 (2012).
A cytoplasmic dynein tail mutation impairs motor processivity.
Ori-McKenney KM, et al. Nat Cell Biol 12, 1228-34 (2010).
Deficits in axonal transport precede ALS symptoms in vivo.
Bilsland LG, et al. Proc Natl Acad Sci U S A 107, 20523-8 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
AAA_9 (pfam12781)
  ATP-binding dynein motor region D5.
MT (pfam12777)
  Microtubule-binding stalk of dynein motor.
Dynein_heavy (pfam03028)
  Dynein heavy chain and region D6 of dynein motor.
AAA_5 (pfam07728)
  AAA domain (dynein-related subfamily).
DHC_N1 (pfam08385)
  Dynein heavy chain, N-terminal region 1.
DHC_N2 (pfam08393)
  Dynein heavy chain, N-terminal region 2.
AAA_22 (pfam13401)
  AAA domain.
DUF4151 (pfam13666)
  Domain of unknown function (DUF4151).
SPEC (cd00176)
  Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
Dynein_heavy (pfam03028)
  Dynein heavy chain and region D6 of dynein motor.
DHC_N1 (pfam08385)
  Dynein heavy chain, N-terminal region 1.
DHC_N2 (pfam08393)
  Dynein heavy chain, N-terminal region 2.
BAR (cl12013)
  The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature.
AAA (cl18944)
  The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Dync1h1 includes H.sapiens DYNC1H1 and R.norvegicus Dync1h1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (35 transcripts, 18 species)
Actinopterygii - bony fishes (33 transcripts, 11 species)
Aves - birds (7 transcripts, 2 species)
Ascidiacea - tunicates (6 transcripts, 2 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (21 transcripts, 11 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (2 transcripts, 1 species)
Malacostraca - crustaceans (2 transcripts, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Mollusca
Gastropoda - gastropods (6 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Annelida
Polychaeta - segmented worms (2 transcripts, 1 species)
Hirudinida - segmented worms (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (3 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Porifera
Demospongiae - sponges (2 transcripts, 1 species)

Ascomycota
Sordariomycetes - ascomycetes (3 transcripts, 2 species)
Eurotiomycetes - ascomycetes (1 transcript, 1 species)
Pezizomycetes - ascomycetes (1 transcript, 1 species)

Basidiomycota
Heterobasidiomycetes - basidiomycetes (1 transcript, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

Oomycetes
Peronosporales - oomycetes (1 transcript, 1 species)

Dictyosteliida
Dictyostelium - cellular slime molds (1 transcript, 1 species)

Apicomplexa
Coccidia - apicomplexans (1 transcript, 1 species)

 

 

 

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