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HomoloGene:9283. Gene conserved in Opisthokonta

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	UBXN1, H.sapiens UBX domain protein 1			NP_001273006.1 297 aa
	UBXN1, P.troglodytes UBX domain protein 1			XP_001155274.1 297 aa
	UBXN1, M.mulatta UBX domain protein 1			XP_001116331.1 297 aa
	UBXN1, C.lupus UBX domain protein 1			XP_005631672.1 296 aa
	UBXN1, B.taurus UBX domain protein 1			NP_001032677.1 297 aa
	Ubxn1, M.musculus UBX domain protein 1			NP_666205.1 297 aa
	Ubxn1, R.norvegicus UBX domain protein 1			NP_001030001.1 297 aa
	ubxn1, X.tropicalis UBX domain protein 1			NP_001004957.1 287 aa
	ubxn1, D.rerio UBX domain protein 1			NP_997772.1 294 aa
	LOC100534742, D.rerio UBX domain-containing protein 1-like			XP_003200015.1 294 aa
	CG8209, D.melanogaster CG8209			NP_648167.1 331 aa
	AgaP_AGAP009841, A.gambiae AgaP_AGAP009841			XP_318954.3 328 aa
	ubxn-1, C.elegans ubxn-1			NP_490978.1 299 aa
	SPAC17C9.11c, S.pombe SPAC17C9.11c			NP_594595.1 240 aa
	MGG_06184, M.oryzae MGG_06184			XP_003712068.1 316 aa
	NCU08955, N.crassa NCU08955			XP_960679.1 318 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

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Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Publications Articles associated with genes and sequences of this homology group.
UBXN1 interferes with Rig-I-like receptor-mediated antiviral immune response by targeting MAVS. Wang P, et al. Cell Rep 3, 1057-70 (2013).
The UBX protein SAKS1 negatively regulates endoplasmic reticulum-associated degradation and p97-dependent degradation. LaLonde DP & Bretscher A. J Biol Chem 286, 4892-901 (2011).
Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation. Schwendemann A, et al. Proc Natl Acad Sci U S A 105, 204-9 (2008).
A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. McNeill H, et al. Biochem J 384, 391-400 (2004).
A novel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems. Ishibashi T, et al. J Biochem 137, 617-23 (2005).
The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function. Wu-Baer F, et al. Mol Cell Biol 30, 2787-98 (2010).
The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor. Li G, et al. Proc Natl Acad Sci U S A 103, 8348-53 (2006).
The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation. Jaleel M, et al. Biochem J 394, 545-55 (2006).
Caenorhabditis elegans UBX cofactors for CDC-48/p97 control spermatogenesis. Sasagawa Y, et al. Genes Cells 15, 1201-15 (2010).
Identification of proteins that interact with mammalian peptide:N-glycanase and implicate this hydrolase in the proteasome-dependent pathway for protein degradation. Park H, et al. Proc Natl Acad Sci U S A 98, 11163-8 (2001).
See all (21)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
UBQ (cl00155) Ubiquitin-like proteins.
UBA (cl00153) Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been suggested that UBA domains are involved in conferring protein target specificity. The domain, a compact three helix bundle, has a conserved GFP-loop and the proline is thought to be critical for binding. The UBA domain is distinct from the conserved three helical domain seen in the N-terminus of EF-TS and eukaryotic NAC proteins.
IncFII_repA (cl11495) IncFII RepA protein family.
SPFH_like (cl19107) core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily.
ApoLp-III_like (cl19113) Apolipophorin-III and similar insect proteins.

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:1289301 Orthology group for M.musculus Ubxn1 includes H.sapiens UBXN1 and R.norvegicus Ubxn1.

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