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HomoloGene:36322. Gene conserved in Tetrapoda Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

TIMP3,  H.sapiens
TIMP metallopeptidase inhibitor 3
NP_000353.1
211 aa
TIMP3,  P.troglodytes
TIMP metallopeptidase inhibitor 3
XP_515097.2
211 aa
TIMP3,  M.mulatta
TIMP metallopeptidase inhibitor 3
NP_001028128.1
211 aa
TIMP3,  C.lupus
TIMP metallopeptidase inhibitor 3
XP_538410.2
211 aa
TIMP3,  B.taurus
TIMP metallopeptidase inhibitor 3
NP_776898.2
211 aa
Timp3,  M.musculus
tissue inhibitor of metalloproteinase 3
NP_035725.1
211 aa
Timp3,  R.norvegicus
TIMP metallopeptidase inhibitor 3
NP_037018.2
211 aa
TIMP3,  G.gallus
TIMP metallopeptidase inhibitor 3
NP_990818.1
212 aa
timp3,  X.tropicalis
TIMP metallopeptidase inhibitor 3
XP_002940366.1
214 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Sorsby fundus dystrophy.



Publications
Articles associated with genes and sequences of this homology group.

Heterogeneous epigenetic regulation of TIMP3 in prostate cancer.
Shinojima T, et al. Epigenetics 7, 1279-89 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
NTR_like (cl02512)
  NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Timp3 includes H.sapiens TIMP3 and R.norvegicus Timp3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 14 species)
Actinopterygii - bony fishes (12 transcripts, 9 species)
Aves - birds (3 transcripts, 2 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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