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HomoloGene:2893. Gene conserved in Euteleostomi

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	ST3GAL5, H.sapiens ST3 beta-galactoside alpha-2,3-sialyltransferase 5			NP_003887.3 418 aa
	ST3GAL5, P.troglodytes ST3 beta-galactoside alpha-2,3-sialyltransferase 5			NP_001032378.1 362 aa
	ST3GAL5, M.mulatta ST3 beta-galactoside alpha-2,3-sialyltransferase 5			XP_001090769.2 418 aa
	ST3GAL5, C.lupus ST3 beta-galactoside alpha-2,3-sialyltransferase 5			XP_854842.2 421 aa
	ST3GAL5, B.taurus ST3 beta-galactoside alpha-2,3-sialyltransferase 5			NP_991376.2 420 aa
	St3gal5, M.musculus ST3 beta-galactoside alpha-2,3-sialyltransferase 5			NP_001030305.1 414 aa
	St3gal5, R.norvegicus ST3 beta-galactoside alpha-2,3-sialyltransferase 5			NP_112627.2 387 aa
	ST3GAL5, G.gallus ST3 beta-galactoside alpha-2,3-sialyltransferase 5			NP_001001192.1 368 aa
	st3gal5, X.tropicalis ST3 beta-galactoside alpha-2,3-sialyltransferase 5			NP_001165301.1 372 aa
	st3gal5, D.rerio ST3 beta-galactoside alpha-2,3-sialyltransferase 5			NP_955810.2 364 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*H.sapiens*
MIM:609056 Amish infantile epilepsy syndrome.

Publications Articles associated with genes and sequences of this homology group.
A mutation in a ganglioside biosynthetic enzyme, ST3GAL5, results in salt & pepper syndrome, a neurocutaneous disorder with altered glycolipid and glycoprotein glycosylation. Boccuto L, et al. Hum Mol Genet 23, 418-33 (2014).
Refractory epilepsy and mitochondrial dysfunction due to GM3 synthase deficiency. Fragaki K, et al. Eur J Hum Genet 21, 528-34 (2013).
Ganglioside GM3 has an essential role in the pathogenesis and progression of rheumatoid arthritis. Tsukuda Y, et al. PLoS One 7, e40136 (2012).
CD4 and CD8 T cells require different membrane gangliosides for activation. Nagafuku M, et al. Proc Natl Acad Sci U S A 109, E336-42 (2012).
Transcriptional activation of human GM3 synthase (hST3Gal V) gene by valproic acid in ARPE-19 human retinal pigment epithelial cells. Song N, et al. BMB Rep 44, 405-9 (2011).
Impairment of neuropsychological behaviors in ganglioside GM3-knockout mice. Niimi K, et al. Biochem Biophys Res Commun 406, 524-8 (2011).
Reducing glycosphingolipid biosynthesis in airway cells partially ameliorates disease manifestations in a mouse model of asthma. Karman J, et al. Int Immunol 22, 593-603 (2010).
Two active and differently N-glycosylated isoforms of human ST3Gal-V are produced from the placental mRNA variant by a leaky scanning mechanism. Zava S, et al. FEBS Lett 584, 1476-80 (2010).
Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti. Yoshikawa M, et al. Proc Natl Acad Sci U S A 106, 9483-8 (2009).
The cytoplasmic tail of GM3 synthase defines its subcellular localization, stability, and in vivo activity. Uemura S, et al. Mol Biol Cell 20, 3088-100 (2009).
See all (52)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
Glyco_transf_29 (pfam00777) Glycosyltransferase family 29 (sialyltransferase).
Glyco_transf_29 (pfam00777) Glycosyltransferase family 29 (sialyltransferase).

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:1339963 Orthology group for M.musculus St3gal5 includes H.sapiens ST3GAL5 and R.norvegicus St3gal5.

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