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HomoloGene:68444. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

SCO2,  H.sapiens
SCO2 cytochrome c oxidase assembly protein
NP_005129.2
266 aa
SCO2,  P.troglodytes
SCO2 cytochrome c oxidase assembly protein
XP_003953968.1
326 aa
LOC720679,  M.mulatta
protein SCO2 homolog, mitochondrial-like
XP_002798471.1
332 aa
SCO2,  C.lupus
SCO cytochrome oxidase deficient homolog 2 (yeast)
XP_538308.4
390 aa
SCO2,  B.taurus
SCO cytochrome oxidase deficient homolog 2 (yeast)
NP_001098963.1
266 aa
Sco2,  M.musculus
SCO cytochrome oxidase deficient homolog 2 (yeast)
NP_001104758.1
255 aa
SCO2,  G.gallus
SCO cytochrome oxidase deficient homolog 2 (yeast)
XP_003640374.1
251 aa
LOC100497895,  X.tropicalis
protein SCO2 homolog, mitochondrial-like
XP_002935088.1
273 aa
sco2,  D.rerio
SCO cytochrome oxidase deficient homolog 2 (yeast)
NP_001038697.1
279 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency.



Publications
Articles associated with genes and sequences of this homology group.

Mutations in SCO2 are associated with autosomal-dominant high-grade myopia.
Tran-Viet KN, et al. Am J Hum Genet 92, 820-6 (2013).
Phenotypic consequences of a novel SCO2 gene mutation.
Verdijk RM, et al. Am J Med Genet A 146A, 2822-7 (2008).
A structural characterization of human SCO2.
Banci L, et al. Structure 15, 1132-40 (2007).
Novel SCO2 mutation (G1521A) presenting as a spinal muscular atrophy type I phenotype.
Tarnopolsky MA, et al. Am J Med Genet A 125A, 310-4 (2004).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Thioredoxin_like (cl00388)
  Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Sco2 includes H.sapiens SCO2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (10 transcripts, 7 species)
Actinopterygii - bony fishes (5 transcripts, 5 species)
Ascidiacea - tunicates (2 transcripts, 2 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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