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HomoloGene:15019. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

RASGRP3,  H.sapiens
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
NP_001132960.1
690 aa
RASGRP3,  P.troglodytes
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
XP_001165459.1
689 aa
RASGRP3,  M.mulatta
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
XP_001106737.1
690 aa
RASGRP3,  C.lupus
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
XP_005630385.1
691 aa
RASGRP3,  B.taurus
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
NP_001069316.1
691 aa
Rasgrp3,  M.musculus
RAS, guanyl releasing protein 3
NP_001159965.1
691 aa
Rasgrp3,  R.norvegicus
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
NP_001101479.1
603 aa
RASGRP3,  G.gallus
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
NP_001006401.1
691 aa
rasgrp3,  X.tropicalis
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
XP_002934496.2
716 aa
rasgrp3,  D.rerio
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
NP_001103934.1
708 aa
rgef-1,  C.elegans
rgef-1
NP_505469.3
654 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Phorbol esters modulate the Ras exchange factor RasGRP3.
Lorenzo PS, et al. Cancer Res 61, 943-9 (2001).
Interactions between drebrin and Ras regulate dendritic spine plasticity.
Biou V, et al. Eur J Neurosci 27, 2847-59 (2008).
RasGRP3 mediates phorbol ester-induced, protein kinase C-independent exocytosis.
Ozaki N, et al. Biochem Biophys Res Commun 329, 765-71 (2005).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EF_hand_5 (pfam13499)
  EF-hand domain pair.
EFh (cd00051)
  EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
EF-hand_7 (pfam13499)
  EF-hand domain pair.
C1 (cl00040)
  Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
RasGEF (cl02485)
  Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
REM (cl02520)
  Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Rasgrp3 includes H.sapiens RASGRP3 and R.norvegicus Rasgrp3.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (12 transcripts, 10 species)
Actinopterygii - bony fishes (4 transcripts, 3 species)
Aves - birds (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (4 transcripts, 2 species)

Porifera
Demospongiae - sponges (4 transcripts, 1 species)

Mollusca
Gastropoda - gastropods (1 transcript, 1 species)

 

 

 

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