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HomoloGene:2587. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PTP4A1,  H.sapiens
protein tyrosine phosphatase type IVA, member 1
NP_003454.1
173 aa
PTP4A1,  P.troglodytes
protein tyrosine phosphatase type IVA, member 1
NP_001233568.1
173 aa
PTP4A1,  M.mulatta
protein tyrosine phosphatase type IVA, member 1
XP_001083424.1
173 aa
PTP4A1,  C.lupus
protein tyrosine phosphatase type IVA, member 1
XP_005627571.1
173 aa
PTP4A1,  B.taurus
protein tyrosine phosphatase type IVA, member 1
NP_001193053.1
173 aa
Ptp4a1,  M.musculus
protein tyrosine phosphatase 4a1
NP_035330.1
173 aa
Ptp4a1,  R.norvegicus
protein tyrosine phosphatase type IVA, member 1
NP_113767.1
173 aa
LOC102547074,  R.norvegicus
protein tyrosine phosphatase type IVA 1-like
XP_006244747.1
173 aa
PTP4A1,  G.gallus
protein tyrosine phosphatase type IVA, member 1
NP_001008461.1
173 aa
ptp4a1,  X.tropicalis
protein tyrosine phosphatase type IVA, member 1
NP_001008023.1
173 aa
ptp4a1,  D.rerio
protein tyrosine phosphatase type IVA, member 1
NP_001007776.2
173 aa
PRL-1,  D.melanogaster
PRL-1
NP_609780.1
176 aa
AgaP_AGAP008708,  A.gambiae
AgaP_AGAP008708
XP_314814.3
177 aa
prl-1,  C.elegans
prl-1
NP_508683.1
190 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Impact of oncogenic protein tyrosine phosphatases in cancer.
Hardy S, et al. Anticancer Agents Med Chem 12, 4-18 (2012).
PRL-3 phosphatase and cancer metastasis.
Al-Aidaroos AQ & Zeng Q. J Cell Biochem 111, 1087-98 (2010).
PRL PTPs: mediators and markers of cancer progression.
Bessette DC, et al. Cancer Metastasis Rev 27, 231-52 (2008).
Analysis of oligodendroglial differentiation using cDNA arrays.
Scarlato M, et al. J Neurosci Res 59, 430-5 (2000).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PTPc (cl00053)
  Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
DSPc (cl00053)
  Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ptp4a1 includes H.sapiens PTP4A1 and R.norvegicus Ptp4a1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (21 transcripts, 15 species)
Actinopterygii - bony fishes (8 transcripts, 8 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (14 transcripts, 12 species)
Arachnida - arachnids (1 transcript, 1 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Annelida
Hirudinida - segmented worms (2 transcripts, 1 species)
Polychaeta - segmented worms (1 transcript, 1 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 2 species)

Platyhelminthes
Trematoda - flatworms (2 transcripts, 2 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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