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HomoloGene:56741. Gene conserved in Eukaryota

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	DESI2, H.sapiens desumoylating isopeptidase 2			NP_057160.2 194 aa
	DESI2, P.troglodytes desumoylating isopeptidase 2			XP_003949780.1 211 aa
	PPPDE1, M.mulatta PPPDE peptidase domain containing 1			XP_001102905.2 194 aa
	DESI2, C.lupus desumoylating isopeptidase 2			XP_005622658.1 193 aa
	PPPDE1, B.taurus PPPDE peptidase domain containing 1			NP_001093854.1 178 aa
	Desi2, M.musculus desumoylating isopeptidase 2			NP_077244.1 194 aa
	Desi2, R.norvegicus desumoylating isopeptidase 2			NP_001013895.1 194 aa
	PPPDE1, G.gallus PPPDE peptidase domain containing 1			NP_001008460.1 193 aa
	desi2, X.tropicalis desumoylating isopeptidase 2			XP_002942241.1 194 aa
	desi2, D.rerio desumoylating isopeptidase 2			NP_001003532.1 196 aa
	CG7222, D.melanogaster CG7222			NP_610613.1 205 aa
	AgaP_AGAP012058, A.gambiae AgaP_AGAP012058			XP_320465.2 203 aa
	F36D4.5, C.elegans F36D4.5			NP_741591.1 334 aa
	AT4G17486, A.thaliana AT4G17486			NP_567528.2 224 aa
	AT5G47310, A.thaliana AT5G47310			NP_199542.1 245 aa
	Os03g0100900, O.sativa Os03g0100900			NP_001048648.1 245 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Publications Articles associated with genes and sequences of this homology group.
Comprehensive analysis of expression profile reveals the ubiquitous distribution of PPPDE peptidase domain 1, a Golgi apparatus component, and its implications in clinical cancer. He Y, et al. Biochimie 95, 1466-75 (2013).
hPNAS-4 inhibits proliferation through S phase arrest and apoptosis: underlying action mechanism in ovarian cancer cells. Li L, et al. Apoptosis 18, 467-79 (2013).
PNAS-4 expression and its relationship to p53 in colorectal cancer. Zhou B, et al. Mol Biol Rep 39, 243-9 (2012).
PNAS4 knockout does not induce obviously neurocytes apoptosis and abnormal development in mice brain. Cai P, et al. Mol Biol Rep 39, 621-8 (2012).
A novel pro-apoptosis gene PNAS4 that induces apoptosis in A549 human lung adenocarcinoma cells and inhibits tumor growth in mice. Yan F, et al. Biochimie 91, 502-7 (2009).
DeSUMOylating isopeptidase: a second class of SUMO protease. Shin EJ, et al. EMBO Rep 13, 339-46 (2012).
Pnas4 is a novel regulator for convergence and extension during vertebrate gastrulation. Yao S, et al. FEBS Lett 582, 2325-32 (2008).
Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). Lee YJ, et al. FEBS Lett 472, 230-4 (2000).

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF862 (pfam05903) PPPDE putative peptidase domain.
Peptidase_C97 (pfam05903) PPPDE putative peptidase domain.

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:1926075 Orthology group for M.musculus Desi2 includes H.sapiens DESI2.

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