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HomoloGene:7885. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PER2,  H.sapiens
period circadian clock 2
NP_073728.1
1255 aa
PER2,  P.troglodytes
period homolog 2 (Drosophila)
XP_001154734.2
1310 aa
PER2,  M.mulatta
period homolog 2 (Drosophila)
XP_001086845.2
1266 aa
PER2,  C.lupus
period circadian clock 2
XP_005635982.1
1273 aa
PER2,  B.taurus
period circadian clock 2
XP_002686632.2
545 aa
Per2,  M.musculus
period circadian clock 2
NP_035196.2
1257 aa
Per2,  R.norvegicus
period circadian clock 2
NP_113866.1
1257 aa
PER2,  G.gallus
period homolog 2 (Drosophila)
NP_989593.1
1344 aa
per2,  D.rerio
period homolog 2 (Drosophila)
NP_878277.1
1404 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Advanced sleep phase syndrome, familial.



Publications
Articles associated with genes and sequences of this homology group.

Organ-specific development characterizes circadian clock gene Per2 expression in rats.
Nishide SY, et al. Am J Physiol Regul Integr Comp Physiol 306, R67-74 (2014).
[Association of genetic variantions of circadian clock genes and risk of breast cancer].
Wang WM, et al. Zhonghua Zhong Liu Za Zhi 35, 236-9 (2013).
Fibroblast PER2 circadian rhythmicity depends on cell density.
Noguchi T, et al. J Biol Rhythms 28, 183-92 (2013).
The mPer2 clock gene modulates cocaine actions in the mouse circadian system.
Brager AJ, et al. Behav Brain Res 243, 255-60 (2013).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PAS_3 (pfam08447)
  PAS fold.
Period_C (pfam12114)
  Period protein 2/3C-terminal region.
PAS (cd00130)
  PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
DUF1720 (pfam08226)
  Domain of unknown function (DUF1720).
Period_C (pfam12114)
  Period protein 2/3C-terminal region.
PAS_11 (pfam14598)
  PAS domain.
PAS_8 (cl02459)
  PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Per2 includes H.sapiens PER2 and R.norvegicus Per2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Actinopterygii - bony fishes (8 transcripts, 5 species)
Aves - birds (3 transcripts, 2 species)

 

 

 

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