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HomoloGene:22495. Gene conserved in Opisthokonta Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

PCSK4,  H.sapiens
proprotein convertase subtilisin/kexin type 4
NP_060043.2
755 aa
PCSK4,  P.troglodytes
proprotein convertase subtilisin/kexin type 4
XP_001172660.2
591 aa
PCSK4,  M.mulatta
proprotein convertase subtilisin/kexin type 4
XP_001095657.1
745 aa
PCSK4,  C.lupus
proprotein convertase subtilisin/kexin type 4
XP_542201.3
764 aa
PCSK4,  B.taurus
proprotein convertase subtilisin/kexin type 4
XP_005209386.1
636 aa
Pcsk4,  M.musculus
proprotein convertase subtilisin/kexin type 4
NP_032819.1
655 aa
Pcsk4,  R.norvegicus
proprotein convertase subtilisin/kexin type 4
NP_598243.1
654 aa
PCSK4,  G.gallus
proprotein convertase subtilisin/kexin type 4
XP_003642925.2
741 aa
pcsk4,  X.tropicalis
proprotein convertase subtilisin/kexin type 4
NP_001072361.1
713 aa
KEX2,  S.cerevisiae
KEX2
NP_014161.1
814 aa
KLLA0D19811g,  K.lactis
KLLA0D19811g
XP_453942.1
756 aa
AGOS_ABL203W,  E.gossypii
AGOS_ABL203W
NP_982744.2
769 aa
krp1,  S.pombe
krp1
NP_594835.1
709 aa
MGG_15291,  M.oryzae
MGG_15291
XP_003716137.1
852 aa
NCU03219,  N.crassa
NCU03219
XP_965319.1
884 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Proprotein convertase subtilisin/kexin type 4 in mammalian fertility: a review.
Gyamera-Acheampong C & Mbikay M. Hum Reprod Update 15, 237-47 (2009).
Impaired fertility in mice deficient for the testicular germ-cell protease PC4.
Mbikay M, et al. Proc Natl Acad Sci U S A 94, 6842-6 (1997).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
P_proprotein (pfam01483)
  Proprotein convertase P-domain.
COG4935 (COG4935)
  Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones].
FU (cl00066)
  Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
P_proprotein (pfam01483)
  Proprotein convertase P-domain.
Peptidases_S8_S53 (cl10459)
  Peptidase domain in the S8 and S53 families.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Pcsk4 includes H.sapiens PCSK4 and R.norvegicus Pcsk4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (8 transcripts, 8 species)
Ascidiacea - tunicates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

 

 

 

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