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HomoloGene

Discover Homologs

HomoloGene:12921. Gene conserved in Amniota

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	NRG4, H.sapiens neuregulin 4			NP_612640.1 115 aa
	NRG4, P.troglodytes neuregulin 4			XP_003314841.1 115 aa
	NRG4, M.mulatta neuregulin 4			XP_001104381.1 115 aa
	NRG4, B.taurus neuregulin 4			XP_005222058.1 116 aa
	Nrg4, M.musculus neuregulin 4			NP_114391.1 115 aa
	Nrg4, R.norvegicus neuregulin 4			NP_001178038.1 115 aa
	NRG4, G.gallus neuregulin 4			NP_001025715.1 112 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Publications Articles associated with genes and sequences of this homology group.
Characterization of the cell membrane-associated products of the Neuregulin 4 gene. Hayes NV, et al. Oncogene 27, 715-20 (2008).
Identification and characterization of novel spliced variants of neuregulin 4 in prostate cancer. Hayes NV, et al. Clin Cancer Res 13, 3147-55 (2007).
Expression of HER3, HER4 and their ligand heregulin-4 is associated with better survival in bladder cancer patients. Memon AA, et al. Br J Cancer 91, 2034-41 (2004).
Neuregulin-4 is a survival factor for colon epithelial cells both in culture and in vivo. Bernard JK, et al. J Biol Chem 287, 39850-8 (2012).
The role of neuregulin4 and HER4 in gastrointestinal malignant lymphoma. Ebi M, et al. Mol Med Rep 4, 1151-5 (2011).
Localization of HRG4, a photoreceptor protein homologous to Unc-119, in ribbon synapse. Higashide T, et al. Invest Ophthalmol Vis Sci 39, 690-8 (1998).
Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase. Harari D, et al. Oncogene 18, 2681-9 (1999).
Neuregulins and cancer. Montero JC, et al. Clin Cancer Res 14, 3237-41 (2008).
Dynamic expression of Erbb pathway members during early mammary gland morphogenesis. Wansbury O, et al. J Invest Dermatol 128, 1009-21 (2008).
Embryo-uterine interactions via the neuregulin family of growth factors during implantation in the mouse. Brown N, et al. Biol Reprod 71, 2003-11 (2004).
See all (17)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
PHA02887 (PHA02887) EGF-like protein; Provisional.
PHA03099 (PHA03099) epidermal growth factor-like protein (EGF-like protein); Provisional.
EGF_CA (cl09941) Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
EGF_CA (cl09941) Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:1933833 Orthology group for M.musculus Nrg4 includes H.sapiens NRG4 and R.norvegicus Nrg4.

UniGene Links to UniGene entries found by comparing the homologous proteins against the transcript database.
*Chordata*
Mammalia - mammals (7 transcripts, 6 species)
Aves - birds (1 transcript, 1 species)

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