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HomoloGene:12921. Gene conserved in Amniota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

NRG4,  H.sapiens
neuregulin 4
NP_612640.1
115 aa
NRG4,  P.troglodytes
neuregulin 4
XP_003314841.1
115 aa
NRG4,  M.mulatta
neuregulin 4
XP_001104381.1
115 aa
NRG4,  B.taurus
neuregulin 4
XP_005222058.1
116 aa
Nrg4,  M.musculus
neuregulin 4
NP_114391.1
115 aa
Nrg4,  R.norvegicus
neuregulin 4
NP_001178038.1
115 aa
NRG4,  G.gallus
neuregulin 4
NP_001025715.1
112 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Localization of HRG4, a photoreceptor protein homologous to Unc-119, in ribbon synapse.
Higashide T, et al. Invest Ophthalmol Vis Sci 39, 690-8 (1998).
Neuregulins and cancer.
Montero JC, et al. Clin Cancer Res 14, 3237-41 (2008).
Dynamic expression of Erbb pathway members during early mammary gland morphogenesis.
Wansbury O, et al. J Invest Dermatol 128, 1009-21 (2008).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
PHA02887 (PHA02887)
  EGF-like protein; Provisional.
PHA03099 (PHA03099)
  epidermal growth factor-like protein (EGF-like protein); Provisional.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nrg4 includes H.sapiens NRG4 and R.norvegicus Nrg4.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (7 transcripts, 6 species)
Aves - birds (1 transcript, 1 species)

 

 

 

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