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HomoloGene

Discover Homologs

HomoloGene:3763. Gene conserved in Euteleostomi

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	NR1D2, H.sapiens nuclear receptor subfamily 1, group D, member 2			NP_005117.3 579 aa
	NR1D2, P.troglodytes nuclear receptor subfamily 1, group D, member 2			XP_516330.2 579 aa
	NR1D2, M.mulatta nuclear receptor subfamily 1, group D, member 2			XP_001089921.2 582 aa
	NR1D2, C.lupus nuclear receptor subfamily 1, group D, member 2			XP_542763.2 576 aa
	NR1D2, B.taurus nuclear receptor subfamily 1, group D, member 2			XP_002698802.1 585 aa
	Nr1d2, M.musculus nuclear receptor subfamily 1, group D, member 2			NP_035714.3 576 aa
	Nr1d2, R.norvegicus nuclear receptor subfamily 1, group D, member 2			NP_671743.1 494 aa
	NR1D2, G.gallus nuclear receptor subfamily 1, group D, member 2			NP_990536.1 549 aa
	nr1d2b, D.rerio nuclear receptor subfamily 1, group D, member 2b			NP_571140.1 578 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

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Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Publications Articles associated with genes and sequences of this homology group.
Real-time analysis of the circadian oscillation of the Rev-Erb β promoter. Yang F, et al. J Atheroscler Thromb 20, 267-76 (2013).
Impact of REV-ERB alpha gene polymorphisms on obesity phenotypes in adult and adolescent samples. Goumidi L, et al. Int J Obes (Lond) 37, 666-72 (2013).
Thiol-disulfide redox dependence of heme binding and heme ligand switching in nuclear hormone receptor rev-erb{beta}. Gupta N & Ragsdale SW. J Biol Chem 286, 4392-403 (2011).
Regulation of adipogenesis by natural and synthetic REV-ERB ligands. Kumar N, et al. Endocrinology 151, 3015-25 (2010).
Nuclear hormone receptors for heme: REV-ERBalpha and REV-ERBbeta are ligand-regulated components of the mammalian clock. Burris TP. Mol Endocrinol 22, 1509-20 (2008).
Structural insight into the constitutive repression function of the nuclear receptor Rev-erbbeta. Woo EJ, et al. J Mol Biol 373, 735-44 (2007).
The orphan Rev-erb nuclear receptors: a link between metabolism, circadian rhythm and inflammation? Ramakrishnan SN & Muscat GE. Nucl Recept Signal 4, e009 (2006).
A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb. Dumas B, et al. Mol Endocrinol 8, 996-1005 (1994).
Rev-erb beta, a new member of the nuclear receptor superfamily, is expressed in the nervous system during chicken development. Bonnelye E, et al. Cell Growth Differ 5, 1357-65 (1994).
Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic function. Bugge A, et al. Genes Dev 26, 657-67 (2012).
See all (40)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
DUF2967 (pfam11179) Protein of unknown function (DUF2967).
NR_DBD_like (cl02596) DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers.
NR_LBD (cl11397) The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators.

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:2449205 Orthology group for M.musculus Nr1d2 includes H.sapiens NR1D2 and R.norvegicus Nr1d2.

UniGene Links to UniGene entries found by comparing the homologous proteins against the transcript database.
*Chordata*
Mammalia - mammals (12 transcripts, 10 species)
Actinopterygii - bony fishes (10 transcripts, 7 species)
Aves - birds (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)
*Arthropoda*
Arachnida - arachnids (1 transcript, 1 species)
*Annelida*
Polychaeta - segmented worms (1 transcript, 1 species)

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