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HomoloGene:40575. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

NID2,  H.sapiens
nidogen 2 (osteonidogen)
NP_031387.3
1375 aa
NID2,  P.troglodytes
nidogen 2 (osteonidogen)
XP_001158556.2
1327 aa
NID2,  M.mulatta
nidogen 2 (osteonidogen)
XP_001098764.1
1387 aa
NID2,  C.lupus
nidogen 2 (osteonidogen)
XP_537445.4
1437 aa
Nid2,  M.musculus
nidogen 2
NP_032721.2
1403 aa
Nid2,  R.norvegicus
nidogen 2 (osteonidogen)
NP_001012005.2
1396 aa
NID2,  G.gallus
nidogen 2 (osteonidogen)
XP_421471.4
1490 aa
nid2,  X.tropicalis
nidogen 2 (osteonidogen)
NP_001090732.1
1520 aa
nid2a,  D.rerio
nidogen 2a (osteonidogen)
XP_005169909.1
1424 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Nidogen-2: a new serum biomarker for ovarian cancer.
Kuk C, et al. Clin Biochem 43, 355-61 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
EGF_3 (pfam12947)
  EGF domain.
LY (smart00135)
  Low-density lipoprotein-receptor YWTD domain.
cEGF (pfam12662)
  Complement Clr-like EGF-like.
nidG2 (cd00255)
  Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a ...
NIDO (cl02648)
  Nidogen-like.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
EGF_3 (pfam12947)
  EGF domain.
TY (cl00150)
  Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases.
EGF_CA (cl09941)
  Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Nid2 includes H.sapiens NID2 and R.norvegicus Nid2.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 11 species)
Actinopterygii - bony fishes (5 transcripts, 3 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Arthropoda
Insecta - insects (13 transcripts, 8 species)

Echinodermata
Echinoidea - sea urchins (1 transcript, 1 species)

 

 

 

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