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HomoloGene:56706. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

MTHFD1L,  H.sapiens
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
NP_001229696.1
979 aa
MTHFD1L,  P.troglodytes
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
XP_518807.3
978 aa
MTHFD1L,  M.mulatta
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
XP_001098522.2
976 aa
MTHFD1L,  C.lupus
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
XP_533450.2
923 aa
MTHFD1L,  B.taurus
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
NP_001069486.1
975 aa
Mthfd1l,  M.musculus
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
NP_758512.3
977 aa
Mthfd1l,  R.norvegicus
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
NP_001101932.2
977 aa
MTHFD1L,  G.gallus
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
XP_004935675.1
934 aa
mthfd1l,  X.tropicalis
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
NP_001120171.1
955 aa
mthfd1l,  D.rerio
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
NP_001229925.1
978 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Enzymatic characterization of human mitochondrial C1-tetrahydrofolate synthase.
Walkup AS & Appling DR. Arch Biochem Biophys 442, 196-205 (2005).
Overexpression of C1-tetrahydrofolate synthase in fetal Down syndrome brain.
Fountoulakis M, et al. J Neural Transm Suppl, 85-93 (2003).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
THF_DHG_CYH (pfam00763)
  Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain.
FolD (COG0190)
  5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism].
NADB_Rossmann (cl09931)
  Rossmann-fold NAD(P)(+)-binding proteins.
THF_DHG_CYH (pfam00763)
  Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain.
Fer4_NifH (cl17203)
  The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion.
NAD_bind_amino_acid_DH (cl17226)
  NAD(P) binding domain of amino acid dehydrogenase-like proteins.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Mthfd1l includes H.sapiens MTHFD1L and R.norvegicus Mthfd1l.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Mammalia - mammals (14 transcripts, 10 species)
Actinopterygii - bony fishes (5 transcripts, 5 species)
Aves - birds (2 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
Amphibia - amphibians (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

 

 

 

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