Warning: The NCBI web site requires JavaScript to function. more...

Sign in to NCBI

HomoloGene

Discover Homologs

HomoloGene:19481. Gene conserved in Boreoeutheria

Download , Links

Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	INCA1, H.sapiens inhibitor of CDK, cyclin A1 interacting protein 1			NP_001161458.1 236 aa
	INCA1, P.troglodytes uncharacterized LOC750532			XP_001174600.2 490 aa
	INCA1, C.lupus inhibitor of CDK, cyclin A1 interacting protein 1			XP_005619967.1 228 aa
	INCA1, B.taurus inhibitor of CDK, cyclin A1 interacting protein 1			XP_002695818.2 247 aa
	Inca1, M.musculus inhibitor of CDK, cyclin A1 interacting protein 1			NP_001239411.1 231 aa
	Inca1, R.norvegicus inhibitor of CDK, cyclin A1 interacting protein 1			NP_001101750.1 249 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Publications Articles associated with genes and sequences of this homology group.
Inhibition of the calcineurin-NFAT interaction by small organic molecules reflects binding at an allosteric site. Kang S, et al. J Biol Chem 280, 37698-706 (2005).
Inhibitor of cyclin-dependent kinase (CDK) interacting with cyclin A1 (INCA1) regulates proliferation and is repressed by oncogenic signaling. Bäumer N, et al. J Biol Chem 286, 28210-22 (2011).
A novel testis protein, RSB-66, interacting with INCA1 (inhibitor of Cdk interacting with cyclin A1). Chen X, et al. Biochem Cell Biol 86, 345-51 (2008).
Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development. Diederichs S, et al. Int J Cancer 116, 207-17 (2005).
The inhibitor of growth protein 5 (ING5) depends on INCA1 as a co-factor for its antiproliferative effects. Zhang F, et al. PLoS One 6, e21505 (2011).
Identification of interaction partners and substrates of the cyclin A1-CDK2 complex. Diederichs S, et al. J Biol Chem 279, 33727-41 (2004).

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
INCA1 (pfam15142) INCA1.
FliX (cl11677) Class II flagellar assembly regulator.

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:2144284 Orthology group for M.musculus Inca1 includes H.sapiens INCA1 and R.norvegicus Inca1.

UniGene Links to UniGene entries found by comparing the homologous proteins against the transcript database.
*Chordata*
Mammalia - mammals (3 transcripts, 3 species)

You are here: NCBI > Homology > HomoloGene