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HomoloGene:8622. Gene conserved in Eukaryota Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

ETHE1,  H.sapiens
ethylmalonic encephalopathy 1
NP_055112.2
254 aa
ETHE1,  P.troglodytes
ethylmalonic encephalopathy 1
XP_512716.2
227 aa
ETHE1,  M.mulatta
ethylmalonic encephalopathy 1
XP_001101587.1
255 aa
ETHE1,  C.lupus
ethylmalonic encephalopathy 1
XP_855241.1
254 aa
ETHE1,  B.taurus
ethylmalonic encephalopathy 1
NP_001029516.1
254 aa
Ethe1,  M.musculus
ethylmalonic encephalopathy 1
NP_075643.1
254 aa
Ethe1,  R.norvegicus
ethylmalonic encephalopathy 1
NP_001099704.1
254 aa
ETHE1,  G.gallus
ethylmalonic encephalopathy 1
XP_424095.4
151 aa
ethe1,  X.tropicalis
ethylmalonic encephalopathy 1
NP_001005706.1
255 aa
ethe1,  D.rerio
ethylmalonic encephalopathy 1
NP_998094.1
279 aa
CG30022,  D.melanogaster
CG30022
NP_725047.2
279 aa
AgaP_AGAP003337,  A.gambiae
AgaP_AGAP003337
XP_314233.3
311 aa
ethe-1,  C.elegans
ethe-1
NP_501684.1
237 aa
GLY3,  A.thaliana
GLY3
NP_564636.2
294 aa
Os01g0667200,  O.sativa
Os01g0667200
NP_001043807.1
305 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Ethylmalonic encephalopathy.



Publications
Articles associated with genes and sequences of this homology group.

Spectroscopic studies on Arabidopsis ETHE1, a glyoxalase II-like protein.
Holdorf MM, et al. J Inorg Biochem 102, 1825-30 (2008).
ETHE1 mutations are specific to ethylmalonic encephalopathy.
Tiranti V, et al. J Med Genet 43, 340-6 (2006).
Structure of an ETHE1-like protein from Arabidopsis thaliana.
McCoy JG, et al. Acta Crystallogr D Biol Crystallogr 62, 964-70 (2006).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Lactamase_B (cl00446)
  Metallo-beta-lactamase superfamily.
Lactamase_B (cl00446)
  Metallo-beta-lactamase superfamily.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ethe1 includes H.sapiens ETHE1 and R.norvegicus Ethe1.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (14 transcripts, 12 species)
Mammalia - mammals (13 transcripts, 12 species)
Ascidiacea - tunicates (4 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Amphibia - amphibians (2 transcripts, 2 species)
Cephalochordata - lancelets (1 transcript, 1 species)

Arthropoda
Insecta - insects (11 transcripts, 11 species)
Arachnida - arachnids (2 transcripts, 2 species)
Branchiopoda - crustaceans (1 transcript, 1 species)
Malacostraca - crustaceans (1 transcript, 1 species)
Maxillopoda - crustaceans (1 transcript, 1 species)

Platyhelminthes
Trematoda - flatworms (3 transcripts, 2 species)
Turbellaria - flatworms (2 transcripts, 1 species)

Cnidaria
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)

Echinodermata
Echinoidea - sea urchins (2 transcripts, 2 species)

Nematoda
Chromadorea - nematodes (1 transcript, 1 species)

Annelida
Polychaeta - segmented worms (1 transcript, 1 species)

Streptophyta
Eudicotyledons - eudicots (37 transcripts, 31 species)
Liliopsida - monocots (7 transcripts, 7 species)
Coniferopsida - conifers (3 transcripts, 3 species)
Bryopsida - mosses (2 transcripts, 1 species)

Bacillariophyta
Bacillariophyceae - diatoms (1 transcript, 1 species)

 

 

 

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