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HomoloGene

Discover Homologs

HomoloGene:910. Gene conserved in Bilateria

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	ARNTL, H.sapiens aryl hydrocarbon receptor nuclear translocator-like			NP_001169.3 625 aa
	ARNTL, P.troglodytes aryl hydrocarbon receptor nuclear translocator-like			XP_001171687.3 626 aa
	ARNTL, M.mulatta aryl hydrocarbon receptor nuclear translocator-like			XP_002799675.1 626 aa
	ARNTL, C.lupus aryl hydrocarbon receptor nuclear translocator-like			XP_005633740.1 632 aa
	ARNTL, B.taurus aryl hydrocarbon receptor nuclear translocator-like			NP_001178099.1 626 aa
	Arntl, M.musculus aryl hydrocarbon receptor nuclear translocator-like			NP_031515.1 626 aa
	Arntl, R.norvegicus aryl hydrocarbon receptor nuclear translocator-like			NP_077338.2 626 aa
	ARNTL, G.gallus aryl hydrocarbon receptor nuclear translocator-like			NP_001001463.1 633 aa
	arntl, X.tropicalis aryl hydrocarbon receptor nuclear translocator-like			XP_002936788.2 502 aa
	cyc, D.melanogaster cycle			NP_524168.2 413 aa
	AgaP_AGAP005655, A.gambiae AgaP_AGAP005655			XP_556301.3 642 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Publications Articles associated with genes and sequences of this homology group.
Impaired glucocorticoid production and response to stress in Arntl-deficient male mice. Leliavski A, et al. Endocrinology 155, 133-42 (2014).
The biological clock is regulated by adrenergic signaling in brown fat but is dispensable for cold-induced thermogenesis. Li S, et al. PLoS One 8, e70109 (2013).
Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes. Nguyen KD, et al. Science 341, 1483-8 (2013).
Global loss of bmal1 expression alters adipose tissue hormones, gene expression and glucose metabolism. Kennaway DJ, et al. PLoS One 8, e65255 (2013).
Downregulation of core clock gene Bmal1 attenuates expression of progesterone and prostaglandin biosynthesis-related genes in rat luteinizing granulosa cells. Chen H, et al. Am J Physiol Cell Physiol 304, C1131-40 (2013).
Bmal1 suppresses cancer cell invasion by blocking the phosphoinositide 3-kinase-Akt-MMP-2 signaling pathway. Jung CH, et al. Oncol Rep 29, 2109-13 (2013).
Bmal1 and β-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced β-cell failure in mice. Lee J, et al. Mol Cell Biol 33, 2327-38 (2013).
Brain and muscle Arnt-like 1 is a key regulator of myogenesis. Chatterjee S, et al. J Cell Sci 126, 2213-24 (2013).
O-GlcNAcylation of BMAL1 regulates circadian rhythms in NIH3T3 fibroblasts. Ma YT, et al. Biochem Biophys Res Commun 431, 382-7 (2013).
The major circadian pacemaker ARNT-like protein-1 (BMAL1) is associated with susceptibility to gestational diabetes mellitus. Pappa KI, et al. Diabetes Res Clin Pract 99, 151-7 (2013).
See all (461)

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
PAS (pfam00989) PAS fold.
PAS (cd00130) PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
PAS_11 (pfam14598) PAS domain.
HLH (cl00081) Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:1096381 Orthology group for M.musculus Arntl includes H.sapiens ARNTL and R.norvegicus Arntl.

UniGene Links to UniGene entries found by comparing the homologous proteins against the transcript database.
*Chordata*
Actinopterygii - bony fishes (23 transcripts, 8 species)
Mammalia - mammals (15 transcripts, 12 species)
Aves - birds (3 transcripts, 3 species)
Amphibia - amphibians (3 transcripts, 2 species)
Amniota - vertebrates (1 transcript, 1 species)
*Arthropoda*
Insecta - insects (11 transcripts, 10 species)
*Echinodermata*
Echinoidea - sea urchins (3 transcripts, 2 species)
*Cnidaria*
Hydrozoa - hydrozoans (1 transcript, 1 species)
Anthozoa - anthozoans (1 transcript, 1 species)
*Mollusca*
Gastropoda - gastropods (1 transcript, 1 species)
*Platyhelminthes*
Trematoda - flatworms (1 transcript, 1 species)

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