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HomoloGene:68166. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

AQP8,  H.sapiens
aquaporin 8
NP_001160.2
261 aa
AQP8,  P.troglodytes
aquaporin 8
XP_523487.2
261 aa
AQP8,  M.mulatta
aquaporin 8
XP_001099227.1
261 aa
AQP8,  C.lupus
aquaporin 8
XP_850126.1
263 aa
AQP8,  B.taurus
aquaporin 8
NP_001193536.1
263 aa
Aqp8,  M.musculus
aquaporin 8
NP_031500.1
261 aa
Aqp8,  R.norvegicus
aquaporin 8
NP_062031.1
263 aa
AQP8,  G.gallus
aquaporin 8
XP_414866.2
244 aa
aqp8,  X.tropicalis
aquaporin 8
NP_001107728.1
269 aa
aqp8a.1,  D.rerio
aquaporin 8a, tandem duplicate 1
NP_001004661.1
260 aa
aqp-4,  C.elegans
aqp-4
NP_505512.3
273 aa
aqp-6,  C.elegans
aqp-6
NP_001256246.1
291 aa
aqp-5,  C.elegans
aqp-5
NP_505691.2
316 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Expression of aquaporin8 in human astrocytomas: correlation with pathologic grade.
Zhu SJ, et al. Biochem Biophys Res Commun 440, 168-72 (2013).
Reconstitution of water channel function and 2D-crystallization of human aquaporin 8.
Agemark M, et al. Biochim Biophys Acta 1818, 839-50 (2012).
Increased female fertility in aquaporin 8-deficient mice.
Su W, et al. IUBMB Life 62, 852-7 (2010).
Aquaporin-8-facilitated mitochondrial ammonia transport.
Soria LR, et al. Biochem Biophys Res Commun 393, 217-21 (2010).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
MIP (cl00200)
  Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
MIP (cl00200)
  Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Aqp8 includes H.sapiens AQP8 and R.norvegicus Aqp8.



UniGene
Links to UniGene entries found by comparing the homologous proteins against the transcript database.

Chordata
Actinopterygii - bony fishes (16 transcripts, 10 species)
Mammalia - mammals (12 transcripts, 10 species)
Amphibia - amphibians (2 transcripts, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)

Arthropoda
Insecta - insects (8 transcripts, 6 species)

Nematoda
Chromadorea - nematodes (2 transcripts, 1 species)

 

 

 

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