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HomoloGene

Discover Homologs

HomoloGene:11345. Gene conserved in Opisthokonta

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Genes Genes identified as putative homologs of one another during the construction of HomoloGene.			Proteins Proteins used in sequence comparisons and their conserved domain architectures.
	ADCK3, H.sapiens aarF domain containing kinase 3			NP_064632.2 647 aa
	ADCK3, P.troglodytes aarF domain containing kinase 3			XP_514248.3 541 aa
	ADCK3, M.mulatta aarF domain containing kinase 3			XP_001089596.1 647 aa
	ADCK3, C.lupus aarF domain containing kinase 3			XP_005623029.1 630 aa
	ADCK3, B.taurus aarF domain containing kinase 3			NP_001039884.1 648 aa
	Adck3, M.musculus aarF domain containing kinase 3			NP_075830.2 645 aa
	Adck3, R.norvegicus aarF domain containing kinase 3			NP_001013203.1 649 aa
	ADCK3, G.gallus aarF domain containing kinase 3			NP_001186342.1 648 aa
	adck3, X.tropicalis aarF domain containing kinase 3			XP_002938888.1 644 aa
	adck3, D.rerio aarF domain containing kinase 3			NP_001002728.2 619 aa
	coq-8, C.elegans coq-8			NP_498014.2 755 aa
	COQ8, S.cerevisiae COQ8			NP_011396.1 501 aa
	KLLA0B00539g, K.lactis KLLA0B00539g			XP_451554.1 557 aa
	AGOS_AAR181W, E.gossypii AGOS_AAR181W			NP_982724.1 543 aa
	abc1, S.pombe abc1			NP_596237.1 610 aa
	MGG_06939, M.oryzae MGG_06939			XP_003709679.1 726 aa
	NCU03823, N.crassa NCU03823			XP_961212.1 774 aa

Protein Alignments

Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST

Regenerate Alignments

Phenotypes Phenotypic information for the genes in this entry imported from model organism databases.
*H.sapiens*
MIM:607426 Coenzyme Q10 deficiency.
MIM:612016 Spinocerebellar ataxia, autosomal recessive 9.

Publications Articles associated with genes and sequences of this homology group.
Adult-onset cerebellar ataxia due to mutations in CABC1/ADCK3. Horvath R, et al. J Neurol Neurosurg Psychiatry 83, 174-8 (2012).
Nonsense mutations in CABC1/ADCK3 cause progressive cerebellar ataxia and atrophy. Gerards M, et al. Mitochondrion 10, 510-5 (2010).
Coenzyme Q supports distinct developmental processes in Caenorhabditis elegans. Asencio C, et al. Mech Ageing Dev 130, 145-53 (2009).
ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency. Lagier-Tourenne C, et al. Am J Hum Genet 82, 661-72 (2008).
CABC1 gene mutations cause ubiquinone deficiency with cerebellar ataxia and seizures. Mollet J, et al. Am J Hum Genet 82, 623-30 (2008).
Differential expression pattern of coq-8 gene during development in Caenorhabditis elegans. Asencio C, et al. Gene Expr Patterns 6, 433-9 (2006).
Isolation of a novel gene, CABC1, encoding a mitochondrial protein that is highly homologous to yeast activity of bc1 complex. Iiizumi M, et al. Cancer Res 62, 1246-50 (2002).
Expression of the human atypical kinase ADCK3 rescues coenzyme Q biosynthesis and phosphorylation of Coq polypeptides in yeast coq8 mutants. Xie LX, et al. Biochim Biophys Acta 1811, 348-60 (2011).
Silencing of ubiquinone biosynthesis genes extends life span in Caenorhabditis elegans. Asencio C, et al. FASEB J 17, 1135-7 (2003).
A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res 122, 133-50 (2004).

Conserved Domains Conserved Domains from CDD found in protein sequences by rpsblast searching.
ABC1 (cl17513) ABC1 family.
APH_ChoK_like (cl17270) Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs) ...

Related Homology Resources Links to curated and computed homology information found in other databases.
MGI:1914676 Orthology group for M.musculus Adck3 includes H.sapiens ADCK3.

UniGene Links to UniGene entries found by comparing the homologous proteins against the transcript database.
*Chordata*
Actinopterygii - bony fishes (20 transcripts, 10 species)
Mammalia - mammals (13 transcripts, 11 species)
Amphibia - amphibians (3 transcripts, 2 species)
Aves - birds (2 transcripts, 1 species)
Amniota - vertebrates (1 transcript, 1 species)
Ascidiacea - tunicates (1 transcript, 1 species)
*Nematoda*
Chromadorea - nematodes (2 transcripts, 2 species)

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