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HomoloGene:8916. Gene conserved in Euteleostomi Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

KIF14,  H.sapiens
kinesin family member 14
1648 aa
KIF14,  P.troglodytes
kinesin family member 14
1648 aa
KIF14,  M.mulatta
kinesin family member 14
1596 aa
KIF14,  C.lupus
kinesin family member 14
1660 aa
Kif14,  M.musculus
kinesin family member 14
1674 aa
Kif14,  R.norvegicus
kinesin family member 14
1757 aa
KIF14,  G.gallus
kinesin family member 14
1641 aa
LOC100493263,  X.tropicalis
kinesin-like protein KIF14-like
1613 aa
kif14,  D.rerio
kinesin family member 14
1307 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

High expression of KIF14 in retinoblastoma: association with older age at diagnosis.
Madhavan J, et al. Invest Ophthalmol Vis Sci 48, 4901-6 (2007).
Profiling genomic copy number changes in retinoblastoma beyond loss of RB1.
Bowles E, et al. Genes Chromosomes Cancer 46, 118-29 (2007).
KIF14 mRNA expression is a predictor of grade and outcome in breast cancer.
Corson TW & Gallie BL. Int J Cancer 119, 1088-94 (2006).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Ribosomal_L31e (pfam01198)
  Ribosomal protein L31e.
KfrA_N (pfam11740)
  Plasmid replication region DNA-binding N-term.
FHA (cl00062)
  Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).
Motor_domain (cl00286)
  Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes.
Prefoldin (cl09111)
  Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
PRK14471 (cl17192)
  F0F1 ATP synthase subunit B; Provisional.
ApoLp-III_like (cl19113)
  Apolipophorin-III and similar insect proteins.

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Kif14 includes H.sapiens KIF14 and R.norvegicus Kif14.




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