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HomoloGene:8438. Gene conserved in Bilateria Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

FGD2,  H.sapiens
FYVE, RhoGEF and PH domain containing 2
NP_775829.2
655 aa
FGD2,  P.troglodytes
FYVE, RhoGEF and PH domain containing 2
XP_527374.2
655 aa
FGD2,  M.mulatta
FYVE, RhoGEF and PH domain containing 2
XP_001116976.1
655 aa
FGD2,  C.lupus
FYVE, RhoGEF and PH domain containing 2
XP_538892.2
657 aa
FGD2,  B.taurus
FYVE, RhoGEF and PH domain containing 2
NP_001069038.1
656 aa
Fgd2,  M.musculus
FYVE, RhoGEF and PH domain containing 2
NP_038738.2
655 aa
Fgd2,  R.norvegicus
FYVE, RhoGEF and PH domain containing 2
NP_001101087.2
655 aa
exc-5,  C.elegans
exc-5
NP_001023038.1
844 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Publications
Articles associated with genes and sequences of this homology group.

Distorting sex ratios.
Willison KR. Nature 402, 131-2 (1999).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
FYVE (pfam01363)
  FYVE zinc finger.
RhoGEF (cl02571)
  Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
PH-like (cl17171)
  Pleckstrin homology-like domain.
FYVE (cl17764)
  FYVE domain; Zinc-binding domain; targets proteins to membrane lipids via interaction with phosphatidylinositol-3-phosphate, PI3P; present in Fab1, YOTB, Vac1, and EEA1.



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Fgd2 includes H.sapiens FGD2 and R.norvegicus Fgd2.


 

 

 

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