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HomoloGene:66151. Gene conserved in Euteleostomi Download , Links
Genes
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins
Proteins used in sequence comparisons and their conserved domain architectures.

USH2A,  H.sapiens
Usher syndrome 2A (autosomal recessive, mild)
NP_996816.2
5202 aa
USH2A,  P.troglodytes
Usher syndrome 2A (autosomal recessive, mild)
XP_514197.2
5202 aa
USH2A,  M.mulatta
Usher syndrome 2A (autosomal recessive, mild)
XP_002801987.1
5099 aa
USH2A,  C.lupus
Usher syndrome 2A (autosomal recessive, mild)
XP_545710.2
5199 aa
USH2A,  B.taurus
Usher syndrome 2A (autosomal recessive, mild)
NP_001178354.1
5204 aa
Ush2a,  M.musculus
Usher syndrome 2A (autosomal recessive, mild)
NP_067383.3
5193 aa
Ush2a,  R.norvegicus
Usher syndrome 2A (autosomal recessive, mild)
NP_001231686.1
5164 aa
USH2A,  G.gallus
Usher syndrome 2A (autosomal recessive, mild)
XP_419417.3
5209 aa
ush2a,  D.rerio
Usher syndrome 2A (autosomal recessive, mild)
XP_697435.5
5351 aa


Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments




Phenotypes
Phenotypic information for the genes in this entry imported from model organism databases.

H.sapiens
Retinitis pigmentosa, AR, without hearing loss.
Usher syndrome, type 2A.



Publications
Articles associated with genes and sequences of this homology group.

A genetic basis for mechanosensory traits in humans.
Frenzel H, et al. PLoS Biol 10, e1001318 (2012).



Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
Laminin_EGF (pfam00053)
  Laminin EGF-like (Domains III and V).
Laminin_G_3 (pfam13385)
  Concanavalin A-like lectin/glucanases superfamily.
Laminin_N (cl02806)
  Laminin N-terminal (Domain VI).
FN3 (cl00065)
  Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
PTX (cl00102)
  Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated ...
Laminin_N (cl02806)
  Laminin N-terminal (Domain VI).
LamG (cl17353)
  Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
EGF_Lam (cl19065)
  Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...



Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Ush2a includes H.sapiens USH2A and R.norvegicus Ush2a.


 

 

 

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