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HomoloGene:44228. Gene conserved in Bilateria Download , Links
Genes identified as putative homologs of one another during the construction of HomoloGene.

Proteins used in sequence comparisons and their conserved domain architectures.

SCRIB,  H.sapiens
scribbled planar cell polarity protein
1655 aa
SCRIB,  P.troglodytes
scribbled homolog (Drosophila)
1662 aa
SCRIB,  C.lupus
scribbled homolog (Drosophila)
1661 aa
SCRIB,  B.taurus
scribbled planar cell polarity protein
1631 aa
Scrib,  M.musculus
scribbled homolog (Drosophila)
1665 aa
Scrib,  R.norvegicus
scribbled planar cell polarity protein
1663 aa
scrib,  X.tropicalis
scribbled planar cell polarity protein
976 aa
scrib,  D.rerio
scribbled homolog (Drosophila)
1724 aa
let-413,  C.elegans
699 aa

Protein Alignments
Protein multiple alignment, pairwise similarity scores and evolutionary distances.

Show Multiple Alignment

Show Pairwise Alignment Scores

Pairwise alignments generated using BLAST
Regenerate Alignments

Articles associated with genes and sequences of this homology group.

Scribble controls NGF-mediated neurite outgrowth in PC12 cells.
Wigerius M, et al. Eur J Cell Biol 92, 213-21 (2013).
Loss of Scribble causes cell competition in mammalian cells.
Norman M, et al. J Cell Sci 125, 59-66 (2012).

Conserved Domains
Conserved Domains from CDD found in protein sequences by rpsblast searching.
LRR_TYP (cl15310)
  Leucine-rich repeats, typical (most populated) subfamily.
LRR_4 (pfam12799)
  Leucine Rich repeats (2 copies).
LRR_8 (pfam13855)
  Leucine rich repeat.
LRR_RI (cd00116)
  Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
LRR_4 (pfam12799)
  Leucine Rich repeats (2 copies).
LRR_8 (pfam13855)
  Leucine rich repeat.
PDZ (cl00117)
  PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

Related Homology Resources
Links to curated and computed homology information found in other databases.
Orthology group for M.musculus Scrib includes H.sapiens SCRIB and R.norvegicus Scrib.




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